Idealised population

In population genetics an idealised population is one that can be described using a number of simplifying assumptions. Models of idealised populations are either used to make a general point, or they are fit to data on real populations for which the assumptions may not hold true. For example, coalescent theory is used to fit data to models of idealised populations.[1] The most common idealized population in population genetics is the Fisher-Wright population after R.A. Fisher and Sewall Wright. Wright-Fisher populations have constant size, and their members can mate and reproduce with any other member. Another example is a Moran model, which has overlapping generations, rather than the non-overlapping generations of the Wright-Fisher model. The complexities of real populations can cause their behavior to match an idealised population with an effective population size that is very different from the census population size of the real population. For sexual diploids, idealized populations will have genotype frequencies related to the allele frequencies according to Hardy-Weinberg equilibrium.

Hardy-Weinberg

In 1908, G. H. Hardy and Wilhelm Weinberg modeled an idealised population to demonstrate that in the absence of selection, migration, random genetic drift, allele frequencies stay constant over time, and that in the presence of random mating, genotype frequencies are related to allele frequencies according to a binomial square principle called the Hardy-Weinberg law.[2]

Usage in population dynamics

A good example of usage idealised population model, in tracking natural population conditions, could be found in a research of Joe Roman and Stephen R. Palumbi (2003). Using genetic diversity data, they questioned: have populations of North Atlantic great whales recovered enough for commercial whaling? To calculate genetic diversity the authors multiply long term effective population size of the females by two, assuming sex ratio 1:1, and then multiply by mitochondrial genes substitution rate, per generation. Making several assumptions according the sex ratio and number of juveniles, they were able to calculate that in contrast to historical records, modern whale populations are far from harvestable range.[3]

Application to population history

Idealised population models could not only provide us with information about present populations conditions but as well are useful in revealing natural history and population dynamics in the past. Using an idealised population model, Anders Eriksson and Andrea Manica (2012) tested the hypothesis of the archaic human admixture with modern humans. The authors compare genome sequences of two human populations, Neanderthals and chimpanzee. Eriksson and Manica created a stepping stone model under which Africa and Eurasia are represented as a string of equal size populations. They concluded that under the stepping stone model, in which Europeans can exchange genetic information with Asians and not with Africans, similarities between Neanderthal genome and Eurasian could be explained by ancient populations structure.[4]

Computer simulations

Usage of models, also allows to perform simulations, including in silica ones, to hypothesize evolutionary outcomes. As an example, PopG is a free computer program that is capable of simulating simultaneous evolution of populations based on Wright-Fisher model. Idealised population model also, could be used in several simple simulations designed for education. So, Charles Darwin: Can you survive? Simulation is designed to introduce general public to the concept of natural selection. Another example is Genetic Drift simulator (Requires an updated Java version), which is designed to visualize influence of genetic drift on natural populations.

References

  1. . Nielsen, Rasmus, and Montgomery Slatkin. An Introduction to Population Genetics: Theory and Applications. Sunderland, MA: Sinauer Associates, 2013. Print.
  2. .Crow, James F. "Population genetics history: a personal view." Annual Review of Genetics 21, no. 1 (1987): 1-22.
  3. Roman, Joe; Palumbi, Stephen R. (2003). "Whales before whaling in the North Atlantic" (PDF). Science. 301 (5632): 508–510. doi:10.1126/science.1084524.
  4. Eriksson, Anders, and Andrea Manica. "Effect of ancient population structure on the degree of polymorphism shared between modern human populations and ancient hominins." Proceedings of the National Academy of Sciences 109, no. 35 (2012): 13956-13960.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.