ITIH2

Identifiers

ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2

External IDs

MGI: 96619 HomoloGene: 1668 GeneCards: ITIH2

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	No data available	Start	7,703,269 bp^[1]
Band	No data available	End	7,749,520 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	No data available	Start	10,094,593 bp^[2]
Band	No data available	End	10,131,396 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity
Cellular component	• blood microparticle • extracellular exosome • extracellular region • endoplasmic reticulum lumen
Biological process	• hyaluronan metabolic process • negative regulation of peptidase activity • negative regulation of endopeptidase activity • post-translational protein modification • cellular protein metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3698


16425

Ensembl


ENSG00000151655


ENSMUSG00000037254

UniProt


P19823


Q61703

RefSeq (mRNA)


NM_002216


NM_010582

RefSeq (protein)


NP_002207


NP_034712

Location (UCSC)

Chr 10: 7.7 – 7.75 Mb

Chr 2: 10.09 – 10.13 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.^[5]^[6]^[7]

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151655 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037254 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. PMID 1385302. doi:10.1016/S0888-7543(05)80287-3.
↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. PMID 10100603. doi:10.1016/S0014-5793(99)00173-8.
↑ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2".

Malki N, Balduyck M, Maes P, et al. (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A.". Biol. Chem. Hoppe-Seyler. 373 (10): 1009–18. PMID 1384548. doi:10.1515/bchm3.1992.373.2.1009.
Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI.". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. PMC 299524 . PMID 2446322. doi:10.1073/pnas.84.23.8272.
Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1988). "Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex.". FEBS Lett. 229 (1): 63–7. PMID 2450046. doi:10.1016/0014-5793(88)80798-1.
Salier JP, Diarra-Mehrpour M, Sesboüé R, et al. (1989). "Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain.". Biol. Chem. Hoppe-Seyler. 369 Suppl: 15–8. PMID 2462430.
Diarra-Mehrpour M, Bourguignon J, Sesboüé R, et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.". Eur. J. Biochem. 179 (1): 147–54. PMID 2465147. doi:10.1111/j.1432-1033.1989.tb14532.x.
Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.". J. Biol. Chem. 264 (27): 15975–81. PMID 2476436.
Schreitmüller T, Hochstrasser K, Reisinger PW, et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins.". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. PMID 3663330. doi:10.1515/bchm3.1987.368.2.963.
Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor.". J. Biol. Chem. 268 (35): 26725–30. PMID 7504674.
Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.". Eur. J. Biochem. 221 (2): 881–8. PMID 7513643. doi:10.1111/j.1432-1033.1994.tb18803.x.
Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J (1994). "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor.". Biochemistry. 33 (23): 7423–9. PMID 7516184. doi:10.1021/bi00189a049.
Enghild JJ, Salvesen G, Thøgersen IB, et al. (1993). "Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin.". J. Biol. Chem. 268 (12): 8711–6. PMID 7682553.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Mizon C, Balduyck M, Albani D, et al. (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains.". J. Immunol. Methods. 190 (1): 61–70. PMID 8601712. doi:10.1016/0022-1759(95)00257-X.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Olsen EH, Rahbek-Nielsen H, Thogersen IB, et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.". Biochemistry. 37 (1): 408–16. PMID 9425062. doi:10.1021/bi971137d.
Mizushima S, Nii A, Kato K, Uemura A (1998). "Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues.". Biol. Pharm. Bull. 21 (2): 167–9. PMID 9514613. doi:10.1248/bpb.21.167.
Flahaut C, Capon C, Balduyck M, et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains.". Biochem. J. 333 (3): 749–56. PMC 1219641 . PMID 9677337.
Hamm A, Veeck J, Bektas N, et al. (2008). "Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis.". BMC Cancer. 8 (25): 25. PMC 2268946 . PMID 18226209. doi:10.1186/1471-2407-8-25.

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ITIH2

See also

References

Further reading