ITIH1

Identifiers

ITIH1, H1P, IATIH, IGHEP1, ITI-HC1, ITIH, SHAP, inter-alpha-trypsin inhibitor heavy chain 1

External IDs

MGI: 96618 HomoloGene: 1667 GeneCards: ITIH1

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	No data available	Start	52,777,592 bp^[1]
Band	No data available	End	52,792,068 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	No data available	Start	30,929,180 bp^[2]
Band	No data available	End	30,943,289 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• peptidase inhibitor activity • calcium ion binding • serine-type endopeptidase inhibitor activity
Cellular component	• extracellular region • blood microparticle • extracellular exosome
Biological process	• negative regulation of peptidase activity • negative regulation of endopeptidase activity • hyaluronan metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3697


16424

Ensembl


ENSG00000055957


ENSMUSG00000006529

UniProt


P19827


Q61702

RefSeq (mRNA)


NM_002215 NM_001166434 NM_001166435 NM_001166436


NM_008406 NM_001306078

RefSeq (protein)


NP_001159906 NP_001159907 NP_001159908 NP_002206


NP_001293007 NP_032432

Location (UCSC)

Chr 3: 52.78 – 52.79 Mb

Chr 14: 30.93 – 30.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ITIH1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000055957 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006529 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. PMID 1385302. doi:10.1016/S0888-7543(05)80287-3.
↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. PMID 10100603. doi:10.1016/S0014-5793(99)00173-8.
↑ "Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1".

Diarra-Mehrpour M, Bourguignon J, Bost F, et al. (1992). "Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1". Biochim. Biophys. Acta. 1132 (1): 114–8. PMID 1380832. doi:10.1016/0167-4781(92)90065-8.
Malki N, Balduyck M, Maes P, et al. (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A". Biol. Chem. Hoppe-Seyler. 373 (10): 1009–18. PMID 1384548. doi:10.1515/bchm3.1992.373.2.1009.
Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. PMC 299524 . PMID 2446322. doi:10.1073/pnas.84.23.8272.
Diarra-Mehrpour M, Bourguignon J, Sesboüé R, et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur. J. Biochem. 179 (1): 147–54. PMID 2465147. doi:10.1111/j.1432-1033.1989.tb14532.x.
Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1989). "Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related". Eur. J. Biochem. 181 (3): 571–6. PMID 2471637. doi:10.1111/j.1432-1033.1989.tb14762.x.
Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. PMID 2476436.
Schreitmüller T, Hochstrasser K, Reisinger PW, et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins". Biol. Chem. Hoppe-Seyler. 368 (8): 963–70. PMID 3663330. doi:10.1515/bchm3.1987.368.2.963.
Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor". J. Biol. Chem. 268 (35): 26725–30. PMID 7504674.
Bost F, Bourguignon J, Martin JP, et al. (1994). "Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene". Eur. J. Biochem. 218 (2): 283–91. PMID 7505744. doi:10.1111/j.1432-1033.1993.tb18376.x.
Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". Eur. J. Biochem. 221 (2): 881–8. PMID 7513643. doi:10.1111/j.1432-1033.1994.tb18803.x.
Diarra-Mehrpour M, Bourguignon J, Sarafan N, et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes". Biochim. Biophys. Acta. 1219 (2): 551–4. PMID 7522574. doi:10.1016/0167-4781(94)90087-6.
Ding M, Umetsu K, Yuasa I, et al. (1995). "Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism". Hum. Genet. 95 (4): 435–6. PMID 7535743. doi:10.1007/BF00208970.
Zhao M, Yoneda M, Ohashi Y, et al. (1995). "Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan". J. Biol. Chem. 270 (44): 26657–63. PMID 7592891. doi:10.1074/jbc.270.44.26657.
Bourguignon J, Diarra-Mehrpour M, Thiberville L, et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence". Eur. J. Biochem. 212 (3): 771–6. PMID 7681778. doi:10.1111/j.1432-1033.1993.tb17717.x.
Olsen EH, Rahbek-Nielsen H, Thogersen IB, et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2". Biochemistry. 37 (1): 408–16. PMID 9425062. doi:10.1021/bi971137d.
Flahaut C, Capon C, Balduyck M, et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains". Biochem. J. 333 ( Pt 3) (Pt 3): 749–56. PMC 1219641 . PMID 9677337.
Flahaut C, Mizon C, Aumercier-Maes P, et al. (1998). "Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications". Eur. J. Biochem. 255 (1): 107–15. PMID 9692908. doi:10.1046/j.1432-1327.1998.2550107.x.
Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. PMID 9756925. doi:10.1074/jbc.273.41.26809.

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ITIH1

See also

References

Further reading