IRS2

IRS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FQW, 3FQX
Identifiers
Aliases	IRS2, IRS-2, insulin receptor substrate 2
External IDs	MGI: 109334 HomoloGene: 2778 GeneCards: IRS2
Gene location (Human) Chr. Chromosome 13 (human)[1] Band No data available Start 109,752,698 bp[1] End 109,786,568 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band No data available Start 10,984,681 bp[2] End 11,008,458 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • insulin receptor binding • protein domain specific binding • 14-3-3 protein binding • phosphatidylinositol 3-kinase binding • protein binding • protein phosphatase binding • protein kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity • 1-phosphatidylinositol-3-kinase activity • signal transducer activity Cellular component • cytoplasm • cytosol • plasma membrane • protein complex Biological process • positive regulation of fatty acid beta-oxidation • positive regulation of glucose import • positive regulation of glycogen biosynthetic process • cellular response to peptide • positive regulation of cell migration • positive regulation of glucose metabolic process • response to glucose • MAPK cascade • mammary gland development • regulation of lipid metabolic process • negative regulation of plasma membrane long-chain fatty acid transport • brain development • positive regulation of mesenchymal cell proliferation • positive regulation of B cell proliferation • positive regulation of cell proliferation • lipid homeostasis • glucose metabolic process • cellular response to insulin stimulus • negative regulation of B cell apoptotic process • cell proliferation • phosphatidylinositol-mediated signaling • cellular response to glucose stimulus • signal transduction • positive regulation of insulin secretion • negative regulation of kinase activity • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of GTPase activity • insulin receptor signaling pathway • axon guidance • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8660	384783
Ensembl	ENSG00000185950	ENSMUSG00000038894
UniProt	Q9Y4H2	P81122
RefSeq (mRNA)	NM_003749	NM_001081212
RefSeq (protein)	NP_003740	NP_001074681
Location (UCSC)	Chr 13: 109.75 – 109.79 Mb	Chr 8: 10.98 – 11.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.^[5]

Function

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.^[6]

Mice lacking IRS2 have a diabetic phenotype^[7] as well as a 40% reduction in brain mass.^[8]

Interactions

IRS2 has been shown to interact with:

• PLCG1,^[9]
• SOCS1,^[10] and
• PIK3R1,^{[11][12][13][14]}

References

Further reading