INPP4A

Identifiers

INPP4A, INPP4, TVAS1, inositol polyphosphate-4-phosphatase type I A

External IDs

MGI: 1931123 HomoloGene: 2871 GeneCards: INPP4A

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	No data available	Start	98,444,854 bp^[1]
Band	No data available	End	98,594,390 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	No data available	Start	37,299,865 bp^[2]
Band	No data available	End	37,410,736 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity • protein binding • hydrolase activity • inositol-3,4-bisphosphate 4-phosphatase activity • phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity • inositol-1,3,4-trisphosphate 4-phosphatase activity
Cellular component	• cytosol • cytoplasm
Biological process	• phosphatidylinositol biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • inositol phosphate metabolic process • signal transduction • dephosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3631


269180

Ensembl


ENSG00000040933


ENSMUSG00000026113

UniProt


Q96PE3


Q9EPW0

RefSeq (mRNA)

NM_001134224 NM_001134225 NM_001566 NM_004027 NM_001351424
NM_001351425 NM_001351426 NM_001351427 NM_001351428 NM_001351429


NM_001290797 NM_001290798 NM_001290799 NM_030266 NM_172971

RefSeq (protein)

NP_001127696 NP_001127697 NP_001557 NP_004018 NP_001338353
NP_001338354 NP_001338355 NP_001338356 NP_001338357 NP_001338358


NP_001277726 NP_001277727 NP_001277728 NP_084542 NP_766559

Location (UCSC)

Chr 2: 98.44 – 98.59 Mb

Chr 1: 37.3 – 37.41 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.^[5]^[6]^[7]

INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000040933 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026113 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J Biol Chem. 270 (27): 16128–33. PMID 7608176. doi:10.1074/jbc.270.27.16128.
↑ Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J Biol Chem. 272 (38): 23859–64. PMID 9295334. doi:10.1074/jbc.272.38.23859.
1 2 "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa".

Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions.". Semin. Cell Dev. Biol. 9 (2): 153–60. PMID 9599410. doi:10.1006/scdb.1997.0220.
Norris FA, Atkins RC, Majerus PW (1997). "Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets.". J. Biol. Chem. 272 (17): 10987–9. PMID 9110986. doi:10.1074/jbc.272.17.10987.
Munday AD, Norris FA, Caldwell KK, et al. (1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3640–5. PMC 22347 . PMID 10097090. doi:10.1073/pnas.96.7.3640.
Joseph RE, Walker J, Norris FA (2000). "Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization.". Cytogenet. Cell Genet. 87 (3-4): 276–7. PMID 10702694. doi:10.1159/000015448.
Shearn CT, Walker J, Norris FA (2001). "Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene.". Biochem. Biophys. Res. Commun. 286 (1): 119–25. PMID 11485317. doi:10.1006/bbrc.2001.5331.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ivetac I, Munday AD, Kisseleva MV, et al. (2005). "The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.". Mol. Biol. Cell. 16 (5): 2218–33. PMC 1087230 . PMID 15716355. doi:10.1091/mbc.E04-09-0799.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

INPP4A

References

Further reading