INHBC

INHBC
Identifiers
AliasesINHBC, IHBC, inhibin beta C, inhibin beta C subunit
External IDsMGI: 105932 HomoloGene: 21142 GeneCards: INHBC
Gene location (Human)
Chr.Chromosome 12 (human)[1]
BandNo data availableStart57,434,760 bp[1]
End57,450,828 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3626

16325

Ensembl

ENSG00000175189

ENSMUSG00000025405

UniProt

P55103

P55104

RefSeq (mRNA)

NM_005538

NM_010565

RefSeq (protein)

NP_005529

NP_034695

Location (UCSC)Chr 12: 57.43 – 57.45 MbChr 10: 127.36 – 127.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.[5][6]

This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175189 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025405 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ H tten G, Neidhardt H, Schneider C, Pohl J (Feb 1995). "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain". Biochem Biophys Res Commun. 206 (2): 608–13. PMID 7826378. doi:10.1006/bbrc.1995.1086.
  6. 1 2 "Entrez Gene: INHBC inhibin, beta C".

Further reading

  • Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction.". Recent Prog. Horm. Res. 56: 417–50. PMID 11237224. doi:10.1210/rp.56.1.417. 
  • Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase.". Cell. 65 (6): 973–82. PMID 1646080. doi:10.1016/0092-8674(91)90549-E. 
  • Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene.". Genomics. 32 (3): 358–66. PMID 8838799. doi:10.1006/geno.1996.0130. 
  • Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia.". Prostate. 34 (1): 34–43. PMID 9428386. doi:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. 
  • Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit.". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. PMID 11134153. doi:10.1210/jc.85.12.4851. 
  • Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.". Mol. Hum. Reprod. 9 (4): 199–203. PMID 12651901. doi:10.1093/molehr/gag029. 
  • Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate.". Endocrinology. 144 (10): 4410–9. PMID 12960042. doi:10.1210/en.2003-0225. 
  • Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein.". J. Reprod. Dev. 52 (4): 487–95. PMID 16627954. doi:10.1262/jrd.17110. 



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