IFIT1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4HOU

Identifiers

Aliases

IFIT1, C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561, interferon induced protein with tetratricopeptide repeats 1

External IDs

MGI: 3650685 HomoloGene: 78213 GeneCards: IFIT1

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	No data available	Start	89,392,546 bp^[1]
Band	No data available	End	89,406,486 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	No data available	Start	34,592,888 bp^[2]
Band	No data available	End	34,601,968 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • RNA binding
Cellular component	• cytoplasm • host cell • cytosol
Biological process	• negative regulation of helicase activity • response to virus • positive regulation of viral genome replication • negative regulation of viral genome replication • negative regulation of defense response to virus by host • cellular response to type I interferon • viral process • intracellular transport of viral protein in host cell • negative regulation of protein binding • type I interferon signaling pathway • innate immune response • regulation of defense response to virus • cellular response to exogenous dsRNA • immune system process • defense response to virus
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3434


667373

Ensembl


ENSG00000185745


ENSMUSG00000079339

UniProt


P09914


n/a

RefSeq (mRNA)


NM_001548 NM_001270927 NM_001270928 NM_001270929 NM_001270930


NM_001101605 NM_001110517

RefSeq (protein)


NP_001257856 NP_001257857 NP_001257858 NP_001257859 NP_001539


n/a

Location (UCSC)

Chr 10: 89.39 – 89.41 Mb

Chr 19: 34.59 – 34.6 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185745 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079339 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lafage M, Clauss I, Couez D, Simonetti J, Wathelet MG, Huez G (Jul 1992). "The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24". Genomics. 13 (2): 458–60. PMID 1377167. doi:10.1016/0888-7543(92)90272-T.
↑ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. PMID 3360121. doi:10.1016/0014-5793(88)80724-5.
↑ "Entrez Gene: IFIT1 interferon-induced protein with tetratricopeptide repeats 1".

Wathelet MG, Clauss IM, Nols CB, et al. (1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.". Eur. J. Biochem. 169 (2): 313–21. PMID 3121313. doi:10.1111/j.1432-1033.1987.tb13614.x.
Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon.". Somat. Cell Mol. Genet. 14 (5): 415–26. PMID 3175763. doi:10.1007/BF01534709.
Kusari J, Szabo P, Grzeschik KH, Sen GC (1987). "Chromosomal localization of the interferon-inducible human gene encoding mRNA 561.". J. Interferon Res. 7 (1): 53–9. PMID 3585080. doi:10.1089/jir.1987.7.53.
Wathelet M, Moutschen S, Defilippi P, et al. (1986). "Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons". Eur. J. Biochem. 155 (1): 11–7. PMID 3753936. doi:10.1111/j.1432-1033.1986.tb09452.x.
Chebath J, Merlin G, Metz R, et al. (1983). "Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA". Nucleic Acids Res. 11 (5): 1213–26. PMC 325791 . PMID 6186990. doi:10.1093/nar/11.5.1213.
Rebouillat D, Marié I, Hovanessian AG (1998). "Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase". Eur. J. Biochem. 257 (2): 319–30. PMID 9826176. doi:10.1046/j.1432-1327.1998.2570319.x.
Guo J, Sen GC (2000). "Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus". J. Virol. 74 (4): 1892–9. PMC 111667 . PMID 10644362. doi:10.1128/JVI.74.4.1892-1899.2000.
Guo J, Peters KL, Sen GC (2000). "Induction of the human protein P56 by interferon, double-stranded RNA, or virus infection". Virology. 267 (2): 209–19. PMID 10662616. doi:10.1006/viro.1999.0135.
Guo J, Hui DJ, Merrick WC, Sen GC (2001). "A new pathway of translational regulation mediated by eukaryotic initiation factor 3". EMBO J. 19 (24): 6891–9. PMC 305884 . PMID 11118224. doi:10.1093/emboj/19.24.6891.
Patzwahl R, Meier V, Ramadori G, Mihm S (2001). "Enhanced Expression of Interferon-Regulated Genes in the Liver of Patients with Chronic Hepatitis C Virus Infection: Detection by Suppression-Subtractive Hybridization". J. Virol. 75 (3): 1332–8. PMC 114039 . PMID 11152506. doi:10.1128/JVI.75.3.1332-1338.2001.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, et al. (2003). "[Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus]". Bioorg. Khim. 29 (2): 175–80. PMID 12708317.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. PMID 16973618. doi:10.1074/jbc.M605771200.

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IFIT1

References

Further reading