HuD (protein)

ELAVL4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELAVL4, HUD, PNEM, HuD, ELAV like neuron-specific RNA binding protein 4, ELAV like RNA binding protein 4
External IDsMGI: 107427 HomoloGene: 40729 GeneCards: ELAVL4
Gene location (Human)
Chr.Chromosome 1 (human)[1]
BandNo data availableStart50,048,014 bp[1]
End50,203,786 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1996

15572

Ensembl

ENSG00000162374

ENSMUSG00000028546

UniProt

P26378

Q61701

RefSeq (mRNA)

NM_001038698
NM_001163397
NM_001163399
NM_010488
NM_001347178

RefSeq (protein)

NP_001033787
NP_001156869
NP_001156871
NP_001334107
NP_034618

Location (UCSC)Chr 1: 50.05 – 50.2 MbChr 4: 110.2 – 110.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.[5][6]

The HuD/ELAVL4 protein is an RNA-binding protein.[7]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[8][9]

Interactions

HuD (protein) has been shown to interact with NXF1.[10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000162374 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028546 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet. 65 (3): 177–8. PMID 8222755. doi:10.1159/000133626.
  6. "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)".
  7. Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.". Cell. 67 (2): 325–33. PMID 1655278. doi:10.1016/0092-8674(91)90184-Z.
  8. Nora Perrone-Bizzozero; Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res. 68 (2): 121–126. PMID 11948657. doi:10.1002/jnr.10175.
  9. Federico Bolognani; Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res. 86 (3): 481–489. PMID 17853436. doi:10.1002/jnr.21473.
  10. Saito, Kuniaki; Fujiwara Toshinobu; Katahira Jun; Inoue Kunio; Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. United States. 321 (2): 291–7. ISSN 0006-291X. PMID 15358174. doi:10.1016/j.bbrc.2004.06.140.

Further reading


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