Henri Termeer

Henri Termeer

Henri Termeer 2012
Born (1946-02-28)28 February 1946[1]
Tilburg, Netherlands[1]
Died 12 May 2017(2017-05-12) (aged 71)
Marblehead, Massachusetts, U.S.
Residence Marblehead, Massachusetts, U.S.[2]
Alma mater Erasmus University
Occupation Executive
Entrepreneur
Board member of Verastem
Genzyme (1983–2011)
Federal Reserve Bank of Boston
ABIOMED Inc
Massachusetts Institute of Technology Corporation
Massachusetts General Hospital
Partners HealthCare System[3][4]
Fellows of Harvard Medical School
Pharmaceutical Research and Manufacturers of America[3]Biotechnology Industry Organization[5]
Moderna Therapeutics (2013-)
Spouse(s) Belinda Termeer
Children Nicholas, Adriana
Parent(s) Jacques and Mary (Van Gorp)

Henri A. Termeer (28 February 1946 – 12 May 2017)[6] was a Dutch biotechnology executive and entrepreneur who is considered a pioneer[2] in corporate strategy in the biotechnology industry for his tenure as CEO at Genzyme.[7] Termeer created a business model[2] adopted by many others in the biotech industry by garnering steep prices— mainly from insurers and government payers— for therapies for rare genetic disorders[2] known as orphan diseases that mainly affect children. Genzyme uses biological processes to manufacture drugs that are not easily copied by generic-drug makers. The drugs are also protected by orphan drug acts in various countries which provides extensive protection from competition and ensures coverage by publicly funded insurers. As CEO of Genzyme from 1981 to 2011, he developed corporate strategies for growth including optimizing institutional embeddedness[8] nurturing vast networks of influential groups and clusters: doctors, private equity, patient-groups, insurance, healthcare umbrella organizations, state and local government, alumni.[9] Termeer is "connected to 311 board members in 17 different organizations across 20 different industries"[8]:296[10] including Verastem, Inc.[1][10] He has the legacy of being the "longest-serving CEO in the biotechnology industry.[2]

He is an "advocate for the Massachusetts biotech industry." "To generate revenues to fund the research, Termeer entered into a number of side ventures including a chemical supplies business, a genetic counseling."[11]:344

Termeer was named as one of the top fifty leaders of thought in orphan drugs and rare diseases in a list published by Terrapin for the World Orphan Drug Congress which included "eminent personalities that have advanced rare disease research."[12]

"Henri was a biotech pioneer long before anyone knew what biotechs were. He founded Genzyme which is often said to have kick started today’s orphan drug biotech M&A frenzy. Henri is definitely a mover/shaker in the biotech world and in the orphan drug space. He will always be known as the guy who figured out how to build a great business by making drugs for rare diseases. An inspiration and pioneer, many of his protégés have since moved on to lead other successful companies in the rare disease and biotech space thanks to his influence."
— World Orphan Drug Congress 2013

Education

Termeer "studied economics at the Economische Hogeschool, Erasmus University, The Netherlands.[1] In 1973 he completed his MBA at Darden School at the University of Virginia.[1] He received an honorary Doctor of Science from the University of Massachusetts.

Norvic

From 1969 to 1971 Termeer was a manager in management services in Norwich, United Kingdom at the Norvic Company, a show company.

Baxter International

He began his career in the medical and healthcare product industry in 1973 when he started working as manager of international product planning for Deerfield, Illinois-based Travenol Laboratories Inc now Baxter. From 1975 to 1976 he was Baxter's international marketing manager. From 1976 to 1979 he was general manager for Travenol GMBH in Munich.

From 1979 to 1981 he was executive vice president of the Hyland Therapeutics division of Baxter Travenol in Glendale, California.[10] In the United States, plasma donors were paid for their time as the time commitment for regular donors is over 200 hours per year. Standards for donating plasma are set by the U.S. Food and Drug Administration (FDA).[13] Almost all plasmapheresis in the US is performed by automated methods such as the Plasma Collection System (PCS2) made by Haemonetics or the Autopheresis-C (Auto-C) made by Fenwal, Inc., a former division of Baxter International. Termeer explained, "This was the beginning of biotechnology. You took plasma and pulled it apart, fractionated it. Hyland sold Factor VIII, Factor IX, immunoglobulins, and albumin. The plasma was collected through plasmapheresis performed at collection centers all around the country. They paid people for plasma. They returned the red cells and paid for the plasma ... There were ethical concerns about the payments. Very vulnerable people were being paid."[1] At that time Baxter was developing tests for Chagas disease which was very prevalent in Latin America, based on feedback indicating that it would be a big market. Termeer was sent to South America to "figure out a way to set up the connections" which was how Baxter operated. After meeting with the military and with the Center for Disease Control he called off the project as unprofitable.[1]

Back in Chicago he was Baxter's International Marketing Manager for several years with the "Artificial Organs Division—artificial kidneys, dialysis equipment, heart/lung machines, stuff like that.[1] This was a period of pioneering work in dialysis and in the development of heart and lung machines for open heart surgeries.[1]

Monica Higgins profiled Termeer as one of the alumni of the Baxter biopharmaceutical industryfirm, the 'Baxter boys'—who produced many of the leaders of the burgeoning biopharmaceutical industry. By 2004 Henri Termeer’s leadership at Genzyme was considered "by many industry observers as exemplary and the firm, Genzyme, has often been seen as a role model for other firms in the industry."[14] Higgins noted in 2004 that at that time, [t]he size and extent of Baxter’s influence overall [was] difficult to ascertain since the biotechnology industry, with eight- to ten-year product development cycles, [was] still in its relative infancy."[14][15]

In December 2011, the non-partisan organization Public Campaign criticized Baxter for spending $10.45 million on lobbying and not paying any taxes during 2008–2010, instead getting $66 million in tax rebates, despite making a profit of $926 million.[16]

Genzyme

According to the Boston Globe staff writer Robert Weisman,[17]

"In the formative years of biotechnology, Genzyme was the industry’s Apple, blazing a pathway for creating protein-based treatments for rare diseases."

In 1983 Termeer became Chairman, CEO and President of Genzyme, a then two-year old start-up biotechnology company, located in Cambridge, Massachusetts.[1] At that time,[18]

"Genzyme was just these professors from MIT and myself and some venture capitalists."
— Termeer 2011

In 1985 he was appointed as their CEO. By 1988 he was Chairman of Genzyme.[1] During those years he held positions at Genzyme in Genzyme Tissue Repair, Strategic Planning & Capital Allocation Committee and Member of Risk Oversight Committee, Genzyme Oncology.[10]

When Genzyme needed a manufacturing facility, Termeer deliberately chose to remain in Massachusetts and use local contractors instead of using the pharmaceuticals cluster in the New Jersey and Philadelphia areas and their more specialized engineering firms. "Massachusetts is home to a vibrant biotechnology cluster, which draws on the region’s strong universities, medical centers, and venture capital firms."[19]

Harvard Business School professor, Michael E. Porter, a leading authority on competitive strategy and the competitiveness taught courses to newly appointed CEOs of very large corporations. Porter described Termeer's strategy as a cluster, the new economics of competition with all members benefiting from "a strong base of supporting functions and institutions."[19] Under Termeer's leadership, Genzyme built a "critical mass" for its "cluster," in Massachusetts, a group of institutions that achieved unusual competitive success in the life sciences industry or biotechnology. with the help of city of Boston and the government of Massachusetts, Termeer undertook a number of initiatives to "improve the labor force, such as offering scholarships and internships to local youth."[19]

Specialty pharmacy

In 2005 Genzyme chose the specialty pharmacy division of PharmaCare, one of the largest pharmaceutical benefit management companies, as national network provider for Thyrogen, Genzyme's specialty drug.[20]

Cerezyme and Gaucher's Disease

In 1991 the first version of Genzyme's orphan drug Alglucerase (brand name Cerezyme), the only treatment for Gaucher's disease,[21] was approved by the FDA.[22]

Termeer explained in a 2005 interview for the Wall Street Journal that in 1991 one treatment of Cerezyme for one patient took 22,000 placentas annually to manufacture, a difficult and expensive procedure.[23] According to the Congressional Office of Technology Assessment cerezyme cost $1.90 per unit including the cost of manufacturing, marketing and distribution. Genzyme charged $3.50 a unit.[23] Imiglucerase was granted orphan drug status in the USA, Australia, and Japan.[24][25][26]

By 1994 Genzyme had a new version of Cerezyme produced in genetically engineered cells in a process that was easier and cheaper.[23] Although imiglucerase costs only less than 37 cents to manufacture, Genzyme charges $3.70 per unit making a 90% profit. The high price of the medication is part of Genzyme's business strategy in order for the biotech firm to undertake research and development for other drugs and to allow them to fund programs that distribute a small portion of production for free.[23] So instead of lowering the price Termeer "decided to use the extra revenue to give additional Cerezyme away free in countries that can't afford to pay the high price. He said Genzyme gives away about 10% of the drug it produces." In order to ensure patients had access to Cerezyme, by 2005 Genzyme had hired 34 people to help patients acquire insurance plans that would cover the cost of their drugs.[23] By 2005 there was still no competition for the drug and with patients desperate for a therapy, most insurers were willing to pay.[23] Genzyme used the profits "to bring new treatments to market for two other rare diseases. It has purchased many small companies to expand into a diversified drug company with cancer, kidney disease and diagnostic products, among others."[23]

By 2005 although Cerezyme cost the average patient (including babies) $200,000 a year, it could cost a single adult patient as much as $520,000 a year even though it cost Genzyme less than $52,000 to manufacture.[23] In 2005 there were only about 4,500 patients on Cerezyme.[23]

Pompe disease

In 1998, two of Crowley's children, Megan and Patrick, were diagnosed with a severe neuromuscular disorder, Glycogen storage disease type II, also called Pompe's disease. In the face of the children's deteriorating health, the family moved to Princeton, New Jersey to be close to doctors specializing in the disease.[27] Crowley worked at Bristol-Myers Squibb, where he held a number of management positions. Frustrated with the slow pace of research on Pompe's disease, Crowley left Bristol-Myers Squibb in March 2000, and took a position as CEO of Novazyme Pharmaceuticals, a biotechnology research company located in Oklahoma City founded by Dr.William Canfield, that was conducting research on a new experimental treatment for the disease.[28]

Biotech executive john Crowley, whose two children were diagnosed in 1998 with Pompe's disease, had been a major force behind the search for a cure. By 2001 Genzyme when acquired Novazyme, Termeer put Crowley in charge Genzyme's global Pompe program, the largest R&D effort in the company’s history, from September 2001 until December 2002. At that time Genzyme was considered to be the world's third largest biotechnology company,[29][30] Genzyme's work eventually bore fruit and in January 2003, Crowley's children received the enzyme replacement therapy for Pompe disease developed by Genzyme. Crowley credits the experimental trial with saving his children's lives.[29] The acquisition of Novazyme by Genzyme, and Crowley's fight to cure Pompe's Disease, was documented in the Harvard Business School Case Study, Novazyme: A Father's Love.[31][32]

According to Higgins by 2004 Henri Termeer’s leadership at Genzyme was celebrated by a number of biotech industry observers as exemplary. Genzyme, in 2004 was seen as a role model for other biotechnology firms.[14]

According to the Wall Street Journal, in 2004 Termeer earned a combined salary and bonus of $3 million. He also had "options valued at between $12.6 million and $32 million in 10 years, based on appreciation of the company's stock of between 5% and 10% a year, according to the company's proxy."[23]

In 2007 Genzyme acquired Bioenvision and the rights to the North American market for clofarabine,[33] (brand name Clofarex), designated by the Food and Drug Administration (FDA) as an orphan drug[34]

In 2007 Termeer as CEO earned a salary of $2.5 million, and non-cash compensation worth $129 million.[35]

From 2007 to 2008 under Termeer as CEO, Genzyme spent more than $8.2 million on lobbying. In 2009 alone, Genzyme had 10 different organizations with a total of 49 lobbyists working on its behalf.[36]

In 1981, before Termeer had joined Genzyme, it was a small firm that "employed 14 people in an office in Chinatown."[37] By 2006 Genzyme with Termeer as CEO Genzyme became a biotech powerhouse with a "payroll of more than 8,000 in 70 offices and plants worldwide, making it the third-largest company of its kind."[37] In 2004 "Termeer was the area’s highest-paid CEO" in 2004, with a "total compensation package worth at least $37.9 million."[37] He was 42nd in the 2006 list of Boston's wealthiest with a networth of $342 million.[37]

In June 2009 Genzyme experienced a manufacturing disaster after contamination with Vesivirus 2117 at their Allston, Massachusetts plant that resulted in shortages of Genzyme drugs including Cerezyme.[38][39] Patients and shareholders depicted Genzyme corporate behaviour as irresponsible and arrogant.[39] Genzyme was fined $175 million by the FDA for manufacturing deficiencies.[39] Genzymes's competitors benefited[39] and Genzyme stocks fell. As a result, 2011 Genzyme was acquired by Sanofi in an hostile takeover in October, 2011—engineered in part by then-CEO of Sanofi, Christopher Viehbacher—[40]:219 for more than $20 billion. Termeer retired.[9][39]

When Termeer left Genzyme his payout was valued at about $138 million,[2][39] making him "one of the biggest all-time winners in biotech."[2]

Biotechnology Industry Organization (BIO)

In 1993 Termeer helped bring about the creation of Biotechnology Industry Organization through the merger of two associations created in the 1980s, the Association of Biotechnology Companies (ABC)—an association of smaller start-ups and their business support network c— and the Industrial Biotechnology Association (IBA)— an organization for the larger biotech firms. Termeer was on the Board of Directors of IBA. Termeer was concerned about potential health-care and FDA reform following the election of Bill Clinton in 1992. He wanted the biotechnology industry to speak with one voice.[41] It was in 1997 while addressing 3,000 people at the BIO international meeting held in Houston that he realized that BIO needed to engage and include patient groups, religious groups, etc.[41] Termeer claimed that BIO was more than lobbying. Under Termeer's leadership as BIO's CEO in 1997 the group successfully exerted pressure which culminated in passage of the Food and Drug Administration Modernization Act of 1997 with criteria "for fast-track drug development, allowed some drug approvals based on one pivotal trial, provided easier patient access to experimental drugs and devices, and renewed the Prescription Drug User Fee program." "The act was very, very helpful," he said. "We set up very good connections between BIO members and the FDA. I felt good about that."[41]

In 2002 Termeer predicted that biotechnology could raise profits that can fund future research. He spoke of Gaucher's disease.[42]

New England Healthcare Institute

In 2002 Termeer was instrumental in bringing together 20 other high-profile health care leaders, to found NEHI, a "nonprofit, applied research health policy organization",[43] as the "New England Healthcare Institute."[44] including Joshua Boger of Vertex Pharmaceuticals, Joseph B. Martin, MD, PhD, then Dean of Harvard Medical School, Samuel O. Thier, MD, then CEO, Partners HealthCare, Fred Telling, PhD, then VP of Corporate Policy and Strategic Management, Pfizer and Charlie Baker, CEO, Harvard Pilgrim Health Care. NEHI members include biotech and pharmaceutical companies, academic health centers, hospitals, medical device companies, employers, payers, patient groups, and others.[44] Termeer is a Chairman Emeritus of the New England Healthcare Institute.

Massachusetts Council of Economic Advisors

In 2008 Governor Deval Patrick appointed Termeer to the Massachusetts Council of Economic Advisors.[43]

Private equity

Erik Gordon from Ann Arbor, a University of Michigan business professor, remarked on Termeer's success "selling some of the world’s most expensive medicines, priced from $200,000 to $300,000 a year" and suggested that following his retirement from Genzyme in 2011, Termeer may be hired by private-equity firms to "pitch deals. Ex-Wyeth CEO Bob Essner became a senior advisor with the Carlyle Group—a "behemoth in private-equity"— on the firm’s health-care investments.[45] Ex-CEO Fred Hassan of Schering-Plough Corporation has been working with private-equity firm Warburg Pincus LLC.[45]

"Henri is the guy you send out as your sales guy to get your real guys in the door. For an investment firm seeking biotech business, “he would be a good guy to have. The CEO of a midmarket biotech company, they’ll take a Henri Termeer call. They would all love to be Henri Termeer one day."
— Erik Gordon 2011

AVEO oncology

By 2012 Termeer was "chairman of cancer drug specialists Aveo Oncology ($AVEO).[9]

Verastem

Termeeer is on the biotechnology start-up Cambridge-based Verastem's Board of Directors with CEO Christoph Westphal.[1][10] Versatem was founded in 2002 by Westphal who also founded the Longwood Fund, which founds and invests in medical companies, and co-founded Longwood portfolio company Flex Pharma, Alnara Pharmaceuticals, OvaScience, Sirtris, Alnylam Pharmaceuticals, Acceleron Pharmaceuticals and Momenta Pharmaceuticals.[3][46] Through the Longwood Fund Westphal is the largest shareholder. Termeer purchased 11,356 shares of Verastem at $9.35 apiece in 2013.[46]

Prosensa

In 2012 Termeer became strategic advisor for Prosensa, a venture-backed biotech[9] to provide advice on corporate strategy and to lobby for Protensa, bringing his "experience in building Genzyme into a world leader in rare diseases." Prosensa's lead compound, a RNA therapy, 051, for an orphan disease known as Duchenne muscular dystrophy (DMD), is being developed by pharmaceutical giant, GlaxoSmithKline (GSK).[9] GSK, which also makes major investments in rare diseases and orphan drugs, licensed 051 in 2009 for "$25 million upfront and another $655 million in milestones."[47] "Prosensa has a technology that could provide an array of RNA therapies for different variants of DMD, which affects about 1 in 3,500 male births and causes muscle wasting that leads to premature death."[9] In 2012 Prosensa was listed by the industry news monitor Fierce Biotech's Fierce 15 as one of their top choices of pharmaceutical firms. Fierce Biotech covers biotechnology news including biopharma deals and clinical trials.[47]

When Prosensa was founded in 2002 in Leiden, Netherlands with Hans Schikan as CEO, it was sustained for several years by patient groups—like Charlie's Funds— a non-profit foundation which provided funds for scientific research on DMD.[48] Charlie's fund received over a million dollars from the documentary, Darius Goes West: The Roll of his Life a documentary about a young DMD patient, Darius Weems' 2005 fund-raising road-trip across the United States. [49] When Prosensa CEO Hans Schikan served at Genzyme, he was "responsible for the global marketing and strategy development of the genetic disease portfolio of orphan medicinal products, which includes the first treatment for Pompe disease." Prosensa, like Genzyme focuses on rare inherited diseases.[9]

By 2012 Propensa had accumulated €55 million in venture capital and had €47 million in the bank. Prosensa's experience in fundraising over the years has provided a model for other rare disease startups."[47]

New Enterprise Associates contributed to Prosensa as its first entry into the European market.[47][50]

Prosensa employs over 80 people. "The company attracted prominent life science ventures capitalists, including Life Science Partners, Abingworth and New Enterprise Associates (NEA), who led a E23m round last January, bringing David Mott, General Partner of NEA and formerly a key executive with MedImmune to the Supervisory Board. Also added to this Supervisory Board in recent months has been Henri Termeer, former Chairman and CEO of Genzyme for some three decades."[51]

ProQR 2014

The Dutch biotech startup ProQR Therapeutics BV, a start-up from Leiden, "licensed a compound from Boston scientists to develop a treatment" for cystic fibrosis focusing on the role of messenger RNA in cystic fibrosis. In 2013 ProQR's CEO Daniel de Boer, whose three-year-old son suffers from cystic fibrosis was introduced to Termeer in Boston by Dutch biotechnology leader Dinko Valerio.[52] Termeer and Valerio are part of a group of well-connected biotech executives financially backing the Dutch biotech ProQR which is focused on the role of messenger RNA in cystic fibrosis. ProQR laid out its proposed terms for a $75 million IPO. ProQR planned "to sell 6.3 million shares at $11 to $13 a share." ProQR is competing with Vertex whose lead drug would serve the same patient population. Termeer and his group "expect to take the program all the way through to commercialization."[53]

Moderna Therapeutics

In April 2013 Termeer joined the board of directors of Moderna Therapeutics, a Cambridge-based biotech company that is developing a platform technology for delivery of mRNA.[54][55][56] By December 2012 Moderna Therapeutics received $40 million "financing led by Flagship Ventures and a consortium of private investors."[54]

CANbridge

In September 2013 China's CANbridge, which is commercializing Western clinical stage pharmaceutical products in China, appointed Termeer as Chief Advisor of their Life Sciences Advisory Board.[57]

Mentorship

In 2015, from his home office in Marblehead, Massachusetts overlooking Marblehead Harbor, Termeer continues to mentor former Genzyme colleagues who are now CEOs of about two dozen smaller companies.[17] Among this group of elite biotech entrepreneurs — the "Genzyme diaspora"— are Geoff McDonough, now CEO of Swedish Orphan Biovitrum AB of Stockholm, Gail Maderis, who runs biotechnology firms and an industry trade group in the San Francisco Bay area, Tom Mathers, CEO at CoLucid Pharmaceuticals Inc, Jeff Albers has a Cambridge-based startup, Blueprint Medicines Corporation and Greg Madison, CEO of New York’s Keryx Biopharmaceuticals Inc.[17]

Awards

Global Genes RARE Project Champions of Hope

In 2012 Termeer received the Lifetime Achievement Award from Nicole Boice, founder and CEO, Global Genes R.A.R.E Project. He was honoured for leading Genzyme for nearly 30 years and helping "to establish Massachusetts as a major center of industrial biotech research and development," for "spearheading the development of rare disease treatments at a time when other pharmaceutical companies were focusing on drugs for much larger patient populations."[59]

Academic

Other affiliations

Termeer is "connected to 311 board members in 17 different organizations across 20 different industries"[10] including AutoImmune Inc., Diacrin, Inc., rEVO Biologics, Inc., Allergan Inc., Genzyme Corporation, Tekla Life Sciences Investors, AVEO Pharmaceuticals, Partners HealthCare System, Federal Reserve Bank of Boston, Biotechnology Industry Organization, Erasmus University, Capital Royalty, Federal Reserve Bank of Atlanta, Colgate W. Darden Graduate School of Business Administration, Longwood Founders Management, Verastem, Moderna Therapeutics, ProQR Therapeutics, CANbridge Life Sciences and the Fellows of Harvard Medical School Termeer serves on their Board of Directors.[3][60]

Lysosomal Therapeutics

Termeer provided financial backing for Lysosomal Therapeutics or N.V.Lysosomal Therapeutics Inc., a fledgling biotech firm in Boston, developing a treatment for Parkinson’s and other neurodegenerative diseases. According to Bloomberg Termeer is the founder of Lysosomal Therapeutics.[10] Termeer is mentoring Lysosomal Therapeutics CEO Dimitri Krainc, who is a neurologist at Massachusetts General Hospital and is originally from Slovenia. According to Krainc, he and Termeer are in "contact by e-mail, phone, or in person weekly. ... “It’s fun to meet with Henri. He listens. He’s got incredibly good judgment. And he’s very focused on the patients."[52]

Philanthropy

Massachusetts General Hospital

Termeer $10 million donation.[9] funds research at the Henri and Belinda Termeer Center for Targeted Therapies at the Massachusetts General Hospital Cancer Center[9] where patients with early and advanced stage cancers enroll in "its fast-growing portfolio of Phase I, Phase II and Phase III clinical trials."[61] Termeer is on the Board of Directors of the MGH and has served on numerous committees with Peter Slavin, Hospital director.[62]

In 2011 Termeer Cathy Minehan, and Chad Gifford— fellow Partners HealthCare Board Members— co-chaired the Massachusetts General Hospital bicentennial. The gala, with 1,000 in attendance, also served as a fundraiser, raising approximately $1 million.[63]

The 2010 Hollywood film entitled Extraordinary Measures starring Harrison Ford as John Crowley [64] working at Genzyme Corporation in Cambridge with Henri Termeer as CEO. It is allegedly based on the true story behind Genzyme's development of Myozyme for the treatment for Pompe disease, a rare enzyme deficiency. Boston Globe staffer Geeta Anand wrote a book on the topic called The Cure.[65]

Crowley was profiled in The Wall Street Journal by Pulitzer Prize-winning journalist Geeta Anand.[66] Anand expanded the profile of Crowley into a book published in 2006, The Cure: How a Father Raised $100 Million – And Bucked the Medical Establishment – In a Quest to Save His Children (ISBN 978-0060734398).[67]

Harrison Ford and Double Feature films optioned the rights to produce a film inspired by Anand’s book and the Crowley family.[68] In April 2009, CBS Films began filming this major motion picture about the Crowley family's quest to save their children's lives. The film, titled Extraordinary Measures[69][70] was released nationwide on January 22, 2010. Directed by Tom Vaughan, Extraordinary Measures stars Brendan Fraser as John Crowley and Keri Russell as Aileen Crowley, and also executive producer Harrison Ford as "Dr. Robert Stonehill" who is a composite character based primarily on Dr. William Canfield and inspired as well by other doctors Crowley worked with.[71]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 Gavin Rynne; Mark Jones, eds. (2013), Conversations with Henri Termeer (PDF), The Life Sciences Foundation Oral History Program, San Francisco, archived from the original (PDF) on 21 July 2015, retrieved 7 July 2015 Oral history conducted by Ted Everson, Jennifer Dionisio, Pei Koay, and Arnold Thackray, May 23, December 7, 2006, August 2, 2007, December 18, 2008 & September 30, 2011
  2. 1 2 3 4 5 6 7 Meg Tirrell (16 February 2011), Genzyme's Termeer May Follow Health Care CEO Path to Private Equity Firms, Bloomberg, retrieved 17 July 2015
  3. 1 2 3 4 "Board of Directors", Verastem, 2015, retrieved 9 July 2015
  4. ↑ "Board of Directors", Partners HealthCare System
  5. ↑ Terrapinn Holdings Ltd (2015). Mr Henri Termeer: Chief Executive Officer, Former Genzyme. Orphan Drug Congress. Retrieved 27 September 2015.
  6. ↑ Marquard, Bryan; Weisman, Robert (13 May 2017). "Henri A. Termeer, key biotech leader who built Genzyme into an industry giant, dies at 71". The Boston Globe. Retrieved 13 May 2017.
  7. ↑ Genzyme’s Termeer, Biotechnology Pioneer, May Sell, Bloomberg, 1 September 2010, retrieved 17 July 2015
  8. 1 2 Porter, Kelley, Kjersten Bunker Whittington, and Walter W. Powell (2005). "The institutional embeddedness of high-tech regions: relational foundations of the Boston biotechnology community". In Stefano Breschi, Franco Malerba. Clusters, networks, and innovation. 261.
  9. 1 2 3 4 5 6 7 8 9 Ryan McBride (13 December 2012), Ex-Genzyme CEO Termeer returns to his roots at biotech Prosensa, retrieved 8 July 2015
  10. 1 2 3 4 5 6 7 Verastem Inc (VSTM:NASDAQ GM), Bloomberg
  11. ↑ Charles Hill, Gareth Jones, Melissa Schilling (2014), Strategic Management: Theory & Cases: An Integrated Approach, Cengage Learning
  12. ↑ "The top 50 thought-leaders in orphan drugs and rare disease" (PDF), World Orphan Drug Congress USA, 2013, retrieved 20 July 2015
  13. ↑ FDA > CDRH > CFR Title 21 Database Search
  14. 1 2 3 Monica C. Higgins (March 2005), Career Imprints: Creating Leaders Across An Industry, Wiley, p. 416, ISBN 978-0-7879-7751-1
  15. ↑ Henri A. Termeer (April 2014). "A Biotechnology Entrepreneur’s Story: Advice to Future Entrepreneurs". In Craig Shimasaki. Biotechnology Entrepreneurship: Starting, Managing, and Leading Biotech. Academic Press. pp. 15–20. ISBN 978-0-12-404730-3.
  16. ↑ Portero, Ashley. "30 Major U.S. Corporations Paid More to Lobby Congress Than Income Taxes, 2008–2010". International Business Times. Archived from the original on December 26, 2011. Retrieved December 26, 2011.
  17. 1 2 3 Robert Weisman (12 July 2015), How Genzyme became a source of biotech executives, Boston Globe, retrieved 17 July 2015
  18. ↑ Henri A. Termeer (10 April 2011), Going out on top, Boston Globe, retrieved 17 July 2015 as told to Scott Helman
  19. 1 2 3 Michael E. Porter (December 1998), "Clusters and the New Economics of Competition", Harvard Business Review
  20. ↑ "PharmaCare Included in Genzyme's Thyrogen(R) Distribution Network". CVS Health. 21 April 2005. Retrieved 24 September 2015.
  21. ↑ Deegan PB, Cox TM. Imiglucerase in the treatment of Gaucher disease: a history and perspective. Drug Des Devel Ther. 2012;6:81-106. doi: 10.2147/DDDT.S14395. Epub 2012 Apr 18. PMID 22563238 (free full text)
  22. ↑ World Health Organization. Regulatory Matters WHO Drug Information 5:3) 1991. p 123
  23. 1 2 3 4 5 6 7 8 9 10 Geeta Anand (November 2005), Why Genzyme Can Charge So Much for Cerezyme, The Wall Street Journal, retrieved 9 July 2015
  24. ↑ "Imiglucerase on Orpha.net: The portal for rare diseases and orphan drugs.".
  25. ↑ Weinreb NJ (August 2008). "Imiglucerase and its use for the treatment of Gaucher's disease". Expert Opin Pharmacother. 9 (11): 1987–2000. PMID 18627336. doi:10.1517/14656566.9.11.1987.
  26. ↑ Starzyk K, Richards S, Yee J, Smith SE, Kingma W (February 2007). "The long-term international safety experience of imiglucerase therapy for Gaucher disease". Mol. Genet. Metab. 90 (2): 157–63. PMID 17079176. doi:10.1016/j.ymgme.2006.09.003.
  27. ↑ Edelstein, Jeff. "LOOK WHO'S TALKING: John Crowley, dad, entrepreneur, and subject of the upcoming film Extraordinary Measures", The Trentonian, January 11, 2010. Accessed February 17, 2011. "Princeton’s Crowley family, from left, Megan, Aileen, John, Patrick, and John Jr. John Crowley, a Princeton Township resident, is the father of two children with Pompe disease."
  28. ↑ "John Crowley On The Today Show 2001". Youtube.com, September, 2001. Accessed June 16, 2008.
  29. 1 2 Crowley, John. "To Save the Children". Notre Dame Lawyer, Spring 2007. Accessed April 4, 2008.
  30. ↑ Amicus Therapeutics, Inc. Executive Profile, BusinessWeek. Accessed April 4, 2008.
  31. ↑ "A Father's Love: Novazyme Pharmaceuticals, Inc. ". Harvard.edu, October, 2002. Accessed June 14, 2011.
  32. ↑ "Journey of the Heart". PharmaVoice.com, January, 2009. Accessed April 8, 2009.
  33. ↑ Associated Press (October 22, 2007). "Genzyme Claims Victory in Prolonged Bid for Bioenvision". International Herald Tribune (France). Retrieved November 10, 2007.
  34. ↑ "Clofarabine", Drugs R D., 5 (4): :213–7, 2004, PMID 15230627
  35. ↑ Forbes (December 2007). "Henri Termeer Profile". Henri Teemer profile. Retrieved July 10, 2008.
  36. ↑ Genzyme Corp. "Client Profile: Summary" Check |url= value (help), Center for Responsive Politics, 2008
  37. 1 2 3 4 Francis Storrs (March 2006), The 50 Wealthiest Bostonians, Boston Magazin, retrieved 8 July 2015
  38. ↑ Erin Ailworth; Robert Weisman (June 17, 2009). "Virus shuts Genzyme plant, holds up drugs for 8,000". The Boston Globe.
  39. 1 2 3 4 5 6 Luke Timmerman (13 May 2013), "Henri Termeer on Startups, Drug Prices, Getting Older (Part 1)", Xconomy, retrieved 9 July 2015
  40. ↑ Nicholas Wright Gillham. Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits. FT Press Science. ISBN 978-0137075447.
  41. 1 2 3 Henri A. Termeer Genzyme, 1995–1997, Washington, D.C.: Biotechnology Industry Organization, retrieved 8 July 2015
  42. ↑ Henri A. Termeer (26 April 2002), Biotechnology - Will It Create a New Industry? (video), MIT, retrieved 17 July 2015
  43. 1 2 "About", Verastem
  44. 1 2 Joshua Boger (7 May 2007), Building on a System of Outreach, Collaboration, Boston Globe, retrieved 8 July 2015
  45. 1 2 James A. White (8 April 2010), Ex-Wyeth CEO Bob Essner Moves to Private Equity’s Carlyle Group, Wall Street Journal, retrieved 17 July 2015
  46. 1 2 Robert Weisman (12 June 2013), Verastem board members Termeer, Clarke go on stock-buying sprees, Boston Globe, retrieved 17 July 2015
  47. 1 2 3 4 "Prosensa – 2012 Fierce 15", Fierce Biotech, 19 September 2012, retrieved 8 July 2015
  48. ↑ Plasse, Sabina Dana (January 22, 2010). "Facebook challenge offers $1 million for research". Idaho Mountain Express. mtexpress.com. Retrieved 16 June 2010.
  49. ↑ Myers, Jack (February 10, 2009). "TED Conference 2009: Inspiration and an Uplifting Spirit of Hope for Future Generations". Huffington Post. huffingtonpost.com. Retrieved 17 June 2010.
  50. ↑ "New Enterprise Associates Closes $2.6 Billion In One Of Largest Venture Funds Ever", Forbes, 25 July 2012, retrieved 8 July 2015
  51. ↑ http://www.liftstream.com/blog/prosensa-gsk-pool-resources-to-drive-drisapersen-in-duchenne/#.VZ1DdflViko
  52. 1 2 Robert Weisman (20 January 2013), Henri Termeer isn’t exactly settling into retirement: Not content to rest on his laurels, the former Genzyme chief stays busy as a tireless advocate for the Massachusetts biotech industry, San Francisco: Boston Globe, retrieved 8 July 2015
  53. ↑ John Carrol (9 September 2014), Termeer-backed ProQR lays out terms for $75M IPO, Fierce Biotech
  54. 1 2 Catherine Shaffer (December 6, 2013). "Moderna Makes Entrance with $40M Round for mRNA Work". BioWorld. Retrieved Dec 11, 2013.
  55. ↑ Henri A. Termeer Joins Moderna Therapeutics Board of Directors, Cambridge, Mass., 30 April 2013, retrieved 8 July 2015
  56. ↑ Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR (September 8, 2013). "Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction". Nature Biotechnology. 31: 898–907. PMC 4058317 Freely accessible. PMID 24013197. doi:10.1038/nbt.2682. Retrieved Dec 11, 2013.
  57. ↑ CANbridge Life Sciences Appoints Former Genzyme CEO, Henri Termeer, to Advisory Board, Beijing: Business Wire, 26 September 2013, retrieved 8 July 2015
  58. ↑ Krughoff, Tracy (15 June 2008). "Henri A. Termeer to Receive 2008 Biotechnology Heritage Award". BIO. Retrieved 5 February 2014.
  59. ↑ "Global Genes and R.A.R.E. Project Announce Tribute to Champions of Hope™ Gala to Honor Rare and Genetic Disease Pioneers, Innovators and Advocates", Global Genes, Dana Point, California, 27 June 2012, retrieved 9 July 2015
  60. ↑ "Board of Directors", Fellows of Harvard Medical School
  61. ↑ "Treatment Programs", Massachusetts General Hospital
  62. ↑ Termeer Center Opening Reception, 2 October 2012, retrieved 9 July 2015Talks by MGH President Dr. Peter Slavin, Mass General Cancer Center Director Dr. Daniel Haber, Termeer Center Director Dr. Keith Flaherty, patient John Murphy and donor Henri Termeer
  63. ↑ Kissinger, Gifford, Termeer attend MGH bicentennial, Boston Globe, 19 September 2011, retrieved 16 July 2015
  64. ↑ Tara Parker-Pope (22 January 2010), "A Father’s Quest to Cure His Children", New York Time blog, retrieved 14 July 2015
  65. ↑ Jeffrey Newman (16 January 2010), Extraordinary Measures True Genzyme Story, retrieved 14 July 2014
  66. ↑ Anand, Geeta. "For His Sick Kids, a Father Struggled to Develop a Cure". The Wall Street Journal, August 26, 2003. Accessed April 4, 2008.
  67. ↑ "Taking Matters Into His Own Hands". Notre Dame Magazine, Spring 2007. Accessed November 28, 2011.
  68. ↑ "Crowley Lures Harrison Ford To CBS". Variety.com, June 9, 2008. Accessed June 16, 2008.
  69. ↑ "Extraordinary Measures". IMDb.com, Inc. Retrieved 2009-09-29.
  70. ↑ "News and Culture: Brenden Fraser’s Untitled Crowley Project Now Has (Another) Terrible Title". Willamette Week. September 24, 2009. Archived from the original on October 23, 2009. Retrieved 2009-09-29.
  71. ↑ "The Successful Effort to Develop Myozyme for Pompe Disease at Genzyme FAQs" Archived January 25, 2010, at the Wayback Machine.
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