Haemodialysis-associated amyloidosis

Haemodialysis-associated amyloidosis
Classification and external resources
Specialty endocrinology
ICD-10 E85.3
ICD-9-CM 277.3
eMedicine med/3384

Haemodialysis-associated amyloidosis is a form of systemic amyloidosis associated with chronic kidney failure.[1]

Presentation

Long-term haemodialysis results in a gradual accumulation of β2 microglobulin, a serum protein, in the blood.[2] It accumulates because it is unable to cross the dialysis filter.

Affected individuals usually present after 5 years of dialysis rarely before that. The tendency of haemodialysis-associated amyloidosis is to be articular in general affecting the joints.

Prevention

Low copper dialysis is theorized to prevent or delay onset.[3]

See also

References

  1. ↑ Miyata T, Oda O, Inagi R, et al. (September 1993). "beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis". J. Clin. Invest. 92 (3): 1243–52. PMC 288264 Freely accessible. PMID 8376584. doi:10.1172/JCI116696.
  2. ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  3. ↑ "BU Amyloid Treatment & Research Program".


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