Hemin

Hemin
Clinical data


AHFS/Drugs.com	Consumer Drug Information
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Intravenous infusion
ATC code	B06AB01 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name Chloro[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2−)]iron(III)
CAS Number	16009-13-5^Y
PubChem CID	5318002
ChemSpider	21160444^Y
UNII	743LRP9S7N
ChEMBL	CHEMBL1628226^N
ECHA InfoCard	100.036.475
Chemical and physical data
Formula	C₃₄H₃₂ClFeN₄O₄
Molar mass	651.94 g/mol
3D model (JSmol)	Interactive image
SMILES OC(=O)CCC=5C1=C\C6=N\C(=C/c3n2[Fe](Cl)N1C(=C\C4=N\C(=C/c2c(C=C)c3C)C(/C)=C4/C=C)/C=5C)C(\C)=C6\CCC(O)=O
InChI InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16?;;^Y Key:BTIJJDXEELBZFS-UKFHATERSA-K^Y
^NY (what is this?) (verify)

Hemin (trade name Panhematin) is an iron-containing porphyrin.^[1] More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.

It is used in the management of porphyria attacks, particularly in acute intermittent porphyria.

It is sometimes distinguished from hematin which has a hydroxide ligand in place of the chloride. However, the terms are sometimes equated.^[2]

Hematin is considered the "X factor" required for the growth of Haemophilus influenzae.^[3]

References

↑ "hemin" at Dorland's Medical Dictionary
↑ "hematin" at Dorland's Medical Dictionary
↑ Sherris, John C.; Ryan, Kenneth J.; Ray, C. L. (2004). Sherris medical microbiology: an introduction to infectious diseases. New York: McGraw-Hill. p. 395. ISBN 0-8385-8529-9.

Information from the American Porphyria Foundation, including emergency delivery information
Hemin at RxList
Hemin at the US National Library of Medicine Medical Subject Headings (MeSH)

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