- Al Hamilton (born 1946), Canadian ice hockey player
- Alfred Douglas-Hamilton, 13th Duke of Hamilton (1862–1940), Scottish nobleman and sailor.
- Alfred Starr Hamilton (1914–2005), U.S. poet
- Alice Hamilton (1869–1970), U.S. medical researcher
- Allen Hamilton (1798–1864), founding father of Fort Wayne, Indiana
- Alvin Hamilton (1912–2004), Canadian politician
- Alwyn Hamilton, author of Rebel of the Sands
- Amanda Hamilton, Scottish nutritionist and television presenter
- Angus Douglas-Hamilton, 15th Duke of Hamilton (1938–2010), Scottish nobleman
- Angus Falconer Douglas-Hamilton (1863–1915), Scottish recipient of the Victoria Cross
- Anne Hamilton, 3rd Duchess of Hamilton (1631–1716), Scottish noblewoman
- Antoine Hamilton (1646–1720), French classical author
- Antony Hamilton (1952–1995), Australian actor
- Argus Hamilton, U.S. comedian
- Arthur Hamilton, U.S. songwriter ("Cry Me a River")
- Arthur Hamilton, Lord Hamilton (born 1942), Scottish judge
- Ashley Hamilton (born 1974), U.S. actor
- Augustus Hamilton (1853–1913), English/New Zealand biologist and ethnologist
- Ben Hamilton (born 1977), U.S. football player
- Bernie Hamilton (born 1928), U.S. actor
- Bethany Hamilton (born 1990), U.S. surfer
- Betty Hamilton (1904–1994), British Trotskyist
- Björn Hamilton (born 1945), Swedish politician
- Blayney Hamilton (1872–1946), Irish cricketer
- Brutus Hamilton (1900–1970), U.S. athlete
- Bryan Hamilton (born 1946), Northern Irish football player
- Carrie Hamilton (1963–2002), U.S. actress
- Chico Hamilton (1921–2013), U.S. jazz band leader
- Christine Hamilton (born 1949), English television personality, wife of former MP Neil Hamilton
- Chuck Hamilton (born 1939), Canadian ice hockey player
- Cicely Hamilton (1872–1952), English actress and writer
- Clark Hamilton, U.S. politician
- Clive Hamilton, Australian Professor of Public Ethics
- Constance Hamilton (1862–1945), Canadian politician
- Cornelius S. Hamilton (1821–1867), U.S. politician
- Cosmo Hamilton (1870–1942), English playwright and novelist
- Craig Hamilton (born 1979), Scottish rugby union player
- Cuthbert Hamilton (1885–1959), British artist
- Cyril Hamilton (1909–1941), English cricketer
- Dana Hamilton (born 1950), U.S. hammered dulcimer player
- Dale E. Hamilton (1909–2002), U.S. collegiate coach
- Darryl Hamilton (1964–2015), U.S. baseball player
- Dean Hamilton (born 1961), Canadian actor and director
- Dennis Hamilton (1944–2012), U.S. basketball player
- Derrick Hamilton (born 1981), U.S. football player
- Derrick Hamilton (basketball) (born 1966), American basketball player
- Des Hamilton (born 1976), English footballer
- Diane Hamilton (born 1925), U.S. heiress; founder of Tradition Records
- Diana Hamilton, British romance novelist
- Don Hamilton (1887–1959), U.S. football player
- Donald Hamilton (1916–2006), U.S. writer
- Donald Cameron Hamilton (1883–1925), New Zealand rugby union player and cricketer
- Doreen Hamilton (born 1951), Canadian politician
- Eamon Hamilton, musician
- Earl Hamilton (1891–1968), U.S. baseball player
- Earl J. Hamilton (1899–1989), U.S. historian
- Edith Hamilton (1867–1963), U.S. writer
- Edmond Hamilton, U.S. sci-fi writer
- Emily Hamilton (born 1971), British actress
- Emma, Lady Hamilton (1761–1815), mistress of Lord Nelson
- Eric Hamilton (born 1953), U.S. football coach
- Erin Hamilton (born 1968), U.S. singer
- Lord Ernest Hamilton (1858–1939), British politician
- Eugene Hamilton (1910–2005), U.S. obstetrician, writer, and medical researcher
- Eugene Lee-Hamilton (1845–1907), English poet
- Fabian Hamilton (born 1955), British politician
- Filippa Palmstierna Hamilton (born 1985), Swedish-French fashion model
- Finley Hamilton (1886–1940), U.S. politician
- Franklin Elmer Ellsworth Hamilton (1866–1918), U.S. theologian; Bishop of the Methodist Episcopal Church
- Frederic C. Hamilton (1927-2016), U.S. oilman and philanthropist
- Gary Hamilton (footballer born 1980), footballer from Northern Ireland
- Gary Hamilton (footballer born 1965), Scottish former footballer
- Gay Hamilton (born 1943), Scottish actress
- Gene Hamilton, U.S. mountain bike racer
- Geoff Hamilton (1936–1996), British gardener and broadcaster
- Gilbert Van Tassel Hamilton (1877–1943), U.S. physician and writer
- Gustav Hamilton (late 1650s - 1691), Anglo-Irish governor of Enniskillen
- Guy Hamilton (1922–2016), English film director
- Hans Hamilton (c. 1758–1822), Anglo-Irish politician
- Hans Hamilton, 4th Baron HolmPatrick (born 1955), British politician
- Harley Hamilton (conductor) (1861–1933), U.S. conductor, composer and violinist
- Harold P. Hamilton (1924–2003), U.S. college president and state government official
- Harry Hamilton (born 1962), U.S. football player.
- Lady Henrietta Hamilton (1780–1857), painter; wife of Sir Charles Hamilton
- Homer Hamilton (1913–1997), Canadian politician
- Hubert Hamilton (1861–1914), British general
- Ion Hamilton, 1st Baron HolmPatrick (1839–1898), Anglo-Irish politician
- Isaac Hamilton (born 1994), U.S. basketball player
- Isaac Miller Hamilton (1864–1952), U.S. banker and politician
- Jacinta Hamilton (born 1983), Australian basketball player
- Jackie Hamilton (1937–2003), British comedian
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- Jackie Hamilton (ice hockey) (born 1925), Canadian ice hockey player
- Jan Hamilton (born 1964), first officer in the British Army to complete gender reassignment from male to female
- Jane Hamilton-Merritt (b. 1947), American photojournalist
- Janet Hamilton (1795–1873), Scottish poet
- Jon Hamilton, American radio science correspondent
- Jordan Hamilton, American professional basketball player
- Jordan Hamilton (soccer), Canadian soccer forward
- José Ignacio García Hamilton (born 1943), Argentine writer
- Josh Hamilton (actor) (born 1969), U.S. actor
- Josh Hamilton (born 1981), U.S. baseball player
- Julian Hamilton (born 1976), Australian musician
- Kathleen Hamilton, Duchess of Abercorn (1905–1990), Mistress of the Robes to Queen Elizabeth II
- Kevan Hamilton (born 1934), Australian rules footballer
- Kenneth Hamilton Scottish pianist
- Kim Hamilton (1932–2013), U.S. actress
- Kipp Hamilton (1935–1981), U.S. actress
- Kyle Hamilton (rower) (born 1978), Canadian rower
- Laird Hamilton (born 1964), U.S. big-wave surfer
- Lance Hamilton (born 1973), New Zealand cricketer
- Larry Hamilton (1931–1996), U.S. professional wrestler
- Laurell K. Hamilton, U.S. writer
- Laurentine Hamilton (1826–1882), U.S. cleric
- Leonard Hamilton (born 1948), U.S. basketball coach
- Lewis Hamilton (born 1985), British Formula One driver
- Lewis Hamilton (footballer) (born 1984), English footballer
- Lillias Hamilton (1858–1925), English doctor and author
- Linda Hamilton (born 1956), U.S. actress
- Lisa Gay Hamilton, U.S. actress
- Lloyd Hamilton (1891–1935), U.S. silent film actor
- Lois Hamilton (1943–1999), U.S. model, author, actress, artist and aviator
- Lowry Hamilton (1869–1936), Irish cricketer
- Lucy Hamilton (also known as China Burg), member of the No Wave band Mars
- Lyn Hamilton, Canadian author of archaeological mystery novels
- Lynell Hamilton (born 1985), U.S. football player
- Lynley Hamilton, Australian cricketer
- Lynne Hamilton, British singer, Evangelist minister
- Mahlon Hamilton (1880–1960), U.S. actor
- Marc Hamilton (born 1944), French Canadian singer from Quebec
- Marci Hamilton, U.S. constitutional law scholar
- Marcus Hamilton (American football) (born 1984), U.S. football player
- Margaret Hamilton (1902–1985), U.S. actress
- Marguerite Hamilton (died 1998), U.S. author
- Marvin Hamilton (born 1988), English footballer
- Masha Hamilton, author and journalist
- Maximilian Reichsgraf von Hamilton (1714-1776), prince bishop of Olmütz
- Max Hamilton (1912–1988), German-born British medical statistician
- Melinda Page Hamilton, U.S. actress
- Michelle Hamilton (born 1948), U.S. Playboy Playmate, model
- Milo Hamilton (1927–2015), U.S. sportscaster
- Milton H. Hamilton, Jr (born 1932), U.S. politician; former majority leader in the Tennessee State Senate
- Morgan C. Hamilton (1809–1893), U.S. politician
- Murray Hamilton (1923–1986), U.S. actor
- Natasha Hamilton (born 1982), English singer and member of Atomic Kitten
- Nick Hamilton (born 1959), U.S. professional wrestling referee
- Norman R. Hamilton (1877–1964), U.S. politician
- Page Hamilton (born 1960), U.S. guitarist, singer and record producer
- Paris Hamilton (born 1981), U.S. football player
- Patricia Hamilton (born 1938), U.S. actress
- Paula Hamilton, U.S. supermodel
- Peggy-Kay Hamilton (1922–1959), U.S. geologist
- Pep Hamilton, U.S. football coach
- Phillip Hamilton (born 1961), U.S. writer
- Pierpont M. Hamilton (1898–1982), United States Army Air Forces officer
- R.H. Hamilton, U.S. sportsman; first head coach of the Baylor college football program from 1899–1900
- Ralph Hamilton (1921–1993), U.S. professional basketball player
- Ray Hamilton (born 1951), U.S. football player
- Raymond Hamilton (1913–1935), U.S. murderer who was executed
- Raymond Hamilton (soccer), U.S. soccer player
- Remy Hamilton (born 1974), U.S. football player
- Robin Hamilton, U.S. politician
- Roland Hamilton (1886–1953), British politician
- Roy Hamilton (1929–1969), U.S. singer
- Roy "Royalty" Hamilton (born 1980) U.S. songwriter
- Roy Hamilton (basketball) (born 1957), U.S. basketball player
- Russ Hamilton, U.S. poker player
- Russ Hamilton (singer) (born 1932), English singer
- Ruth Hamilton (1898–2008), U.S. radio talk show host and politician
- Sarah Jane Hamilton (born 1971), U.S. pornographic actress
- Schuyler Hamilton, (1822–1903), U.S. soldier
- Sean Hamilton US radio host
- Simon Hamilton, Northern Ireland politician
- Suzanna Hamilton (born 1960), English actress
- Suzy Favor-Hamilton (born 1968), U.S. middle distance runner
- Tang Hamilton (born 1978), U.S. basketball player
- Todd Hamilton, U.S. professional golfer
- Trevor Hamilton (born 1982), Northern Irish murderer
- Tyler Hamilton (born 1971), U.S. professional road bicycle racer
- Tyler Hamilton (reporter) (born 1970), Canadian reporter
- Venson Hamilton (born 1977), U.S.-Spanish basketball player
- Victoria Hamilton (born 1971), British actress
- W. D. Hamilton, British evolutionary biologist
- W. O. Hamilton, U.S. athletics coach
- Walter Alfred Hamilton (1863–1955), Australian politician
- Walter Kerr Hamilton (1808–1869), Anglican Bishop of Salisbury
- Walter Richard Pollock Hamilton (1856–1879), Irish recipient of the Victoria Cross
- Wes Hamilton (born 1953), U.S. football player
- Wilbur H. Hamilton (1909-1964), American businessman and politician
- Willoughby Hamilton (1864–1943), Irish tennis player
- Zendon Hamilton (born 1975), U.S. basketball player
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