HOXA4
Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.[5][6]
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.[7] Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[5]
See also
References
Further reading
- Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell. 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4.
- Buettner R, Yim SO, Hong YS, et al. (1991). "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.". Mol. Cell. Biol. 11 (7): 3573–83. PMC 361102 . PMID 1675427.
- McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics. 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X.
- Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation. 45 (1): 61–9. PMID 1981366. doi:10.1111/j.1432-0436.1990.tb00458.x.
- Ferguson-Smith AC, Fienberg A, Ruddle FH (1989). "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.". Genomics. 5 (2): 250–8. PMID 2571574. doi:10.1016/0888-7543(89)90054-2.
- Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome. 31 (2): 745–56. PMID 2576652. doi:10.1139/g89-133.
- Verlinsky Y, Morozov G, Gindilis V, et al. (1995). "Homeobox gene expression in human oocytes and preembryos.". Mol. Reprod. Dev. 41 (2): 127–32. PMID 7654365. doi:10.1002/mrd.1080410202.
- Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. PMID 8646877. doi:10.1159/000134320.
- Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177–81. PMID 8688592. doi:10.1007/BF02072541.
- Duluc I, Lorentz O, Fritsch C, et al. (1997). "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells.". J. Cell. Sci. 110 (11): 1317–24. PMID 9202392.
- Stelnicki EJ, Kömüves LG, Kwong AO, et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.". J. Invest. Dermatol. 110 (2): 110–5. PMID 9457903. doi:10.1046/j.1523-1747.1998.00092.x.
- Verlinsky Y, Morozov G, Verlinsky O, et al. (1998). "Isolation of cDNA libraries from individual human preimplantation embryos.". Mol. Hum. Reprod. 4 (6): 571–5. PMID 9665340. doi:10.1093/molehr/4.6.571.
- "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074. doi:10.1101/gr.8.11.1097.
- Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology. 65 (2): 50–62. PMID 11857506. doi:10.1002/tera.10009.
- Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.". Haematologica. 87 (6): 569–77. PMID 12031912.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Méchine-Neuville A, Lefebvre O, Bellocq JP, et al. (2003). "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7. PMID 12520199.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
- Strathdee G, Sim A, Parker A, et al. (2007). "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL.". Leukemia. 20 (7): 1326–9. PMID 16688227. doi:10.1038/sj.leu.2404254.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |