HNRNPLL
| HNRNPLL | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | HNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like | ||||||||||||||||
| External IDs | MGI: 1919942 HomoloGene: 26701 GeneCards: HNRNPLL | ||||||||||||||||
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| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||
| RefSeq (protein) | |||||||||||||||||
| Location (UCSC) | Chr 2: 38.56 – 38.6 Mb | Chr 17: 80.03 – 80.06 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
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Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene. [3]
Function
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008].
References
Further reading
- Lai, Y.; Song, M.; Hakala, K.; Weintraub, S. T.; Shiio, Y. (2011). "Proteomic Dissection of the von Hippel–Lindau (VHL) Interactome". Journal of Proteome Research. 10 (11): 5175–5182. PMC 3208728
. PMID 21942715. doi:10.1021/pr200642c. - Topp, J. D.; Jackson, J.; Melton, A. A.; Lynch, K. W. (2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA. 14 (10): 2038–2049. PMC 2553740 . PMID 18719244. doi:10.1261/rna.1212008.
- Wu, Z.; Yates, A. L.; Hoyne, G. F.; Goodnow, C. C. (2010). "Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation". The Journal of Immunology. 185 (1): 231–238. PMID 20505149. doi:10.4049/jimmunol.0903625.
- Oberdoerffer, S.; Moita, L. F.; Neems, D.; Freitas, R. P.; Hacohen, N.; Rao, A. (2008). "Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–691. PMC 2791692 . PMID 18669861. doi:10.1126/science.1157610.
- Fedorova, O. A.; Moiseeva, T. N.; Nikiforov, A. A.; Tsimokha, A. S.; Livinskaya, V. A.; Hodson, M.; Bottrill, A.; Evteeva, I. N.; Ermolayeva, J. B.; Kuznetzova, I. M.; Turoverov, K. K.; Eperon, I.; Barlev, N. A. (2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications. 416 (3–4): 258–265. PMID 22079093. doi:10.1016/j.bbrc.2011.10.126.
- Shur, I.; Ben-Avraham, D.; Benayahu, D. (2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene. 334: 113–121. PMID 15256261. doi:10.1016/j.gene.2004.03.012.
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