HLA-Cw7
HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw7 is determined by the antibody recognition of α7 subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M locus.[1] Cw7 and Cw*07 are almost synonymous in meaning. Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7.
Serotype
Cw7 recognition of some HLA Cw*07 gene products[2]
Cw*07 |
Cw7 |
Sample |
allele | % |
size (N) |
*0701 | 74 | 304 |
*0702 | 68 | 976 |
Distribution
HLA Cw*0701 frequenciesStudy population |
Freq. (in %)[3] |
---|
|
---|
Cameroon Pygmy Baka |
25.0 |
---|
Ireland South |
21.2 |
---|
German Essen |
20.9 |
---|
Cameroon Sawa |
19.2 |
---|
Ireland Northern |
18.7 |
---|
France West |
18.1 |
---|
Kenya |
17.8 |
---|
Burkina Faso Fulani |
17.4 |
---|
Australia New South Wales |
17.3 |
---|
France South East |
17.3 |
---|
Morocco 'Berber' Nador Me… |
16.7 |
---|
Sudanese |
16.5 |
---|
United Kingdom Caucasians |
16.1 |
---|
Uganda Kampala |
16.0 |
---|
Brazil |
15.6 |
---|
USA Caucasian (2) |
15.5 |
---|
Kenya Nandi |
15.2 |
---|
Pakistan Baloch |
15.2 |
---|
Burkina Faso Rimaibe |
14.9 |
---|
Finland |
14.4 |
---|
Czech Republic |
14.2 |
---|
Swiss Geneva |
13.6 |
---|
South Africa Natal Tamil |
13.5 |
---|
Cameroon Bamileke |
13.0 |
---|
India Khandesh Pawra |
13.0 |
---|
Cameroon Beti |
12.9 |
---|
Tunisia |
12.6 |
---|
India New Delhi |
12.5 |
---|
Saudi Arabia Guraiat and … |
12.3 |
---|
Turkey |
12.3 |
---|
Zambia Lusaka |
12.2 |
---|
Kenya Luo |
11.7 |
---|
Burkina Faso Mossi |
11.3 |
---|
South Korea (1) |
11.1 |
---|
Spain Eastern Andalusia |
11.0 |
---|
USA Hispanic |
10.9 |
---|
Lebanon |
10.8 |
---|
India Tamil Nadu Nadar |
10.7 |
---|
Zimbabwe Harare Shona |
10.6 |
---|
Russia Arkhangelsk Pomors |
10.0 |
---|
Georgia Tibilisi Georgian… |
9.8 |
---|
Mexico Zaptotec Oaxaca |
9.7 |
---|
Israel Arab Druse |
9.0 |
---|
Senegal Niokholo Mandenka |
8.7 |
---|
USA North American Native… |
8.6 |
---|
Pakistan Sindhi |
8.3 |
---|
India North Delhi |
8.0 |
---|
Iran Baloch |
7.8 |
---|
Thailand |
7.7 |
---|
Singapore Riau Malay |
7.5 |
---|
India West Coast Parsis |
7.0 |
---|
Georgia Tibilisi Kurds |
6.9 |
---|
Pakistan Kalash |
6.5 |
---|
Mali Bandiagara |
6.2 |
---|
Pakistan Burusho |
5.6 |
---|
Pakistan Karachi Parsi |
5.5 |
---|
Pakistan Pathan |
5.5 |
---|
Russia Murmansk Saomi |
4.0 |
---|
Singapore Javanese Indone… |
4.0 |
---|
India Mumbai Marathas |
3.7 |
---|
Australia Indig. Cape Yor… |
3.4 |
---|
Pakistan Brahui |
3.4 |
---|
India West Bhils |
3.0 |
---|
China North Han |
2.9 |
---|
Jordan Amman |
2.8 |
---|
China Inner Mongolia |
2.5 |
---|
Italy North Pavia |
2.5 |
---|
Russia Nenets |
2.4 |
---|
China Qinghai Hui |
2.3 |
---|
Australia Indig. Groote E… |
2.1 |
---|
Russia Tuva (2) |
2.0 |
---|
USA Hawaii Okinawa |
1.9 |
---|
USA Asian |
1.8 |
---|
China South Han |
1.6 |
---|
China Beijing |
1.5 |
---|
Papua New Guinea Wanigela |
1.4 |
---|
|
---|
Allele frequencies presented, only |
HLA Cw*0702 frequenciesStudy population |
Freq. (in %)[3] |
---|
|
---|
Venezuela Sierra de Perij… |
71.4 |
---|
PNG New Britain Rabaul |
57.1 |
---|
Mexico Mixtec Oaxaca |
33.3 |
---|
China Yunnan Lisu |
32.9 |
---|
Taiwan Taroko |
31.8 |
---|
China Yunnan Nu |
30.7 |
---|
Venezuela Perja Mountain … |
30.3 |
---|
PNG Madang |
30.2 |
---|
Mexico Zaptotec Oaxaca |
28.4 |
---|
Taiwan Tsou |
27.5 |
---|
Mexico Mixe Oaxaca |
26.4 |
---|
Russia Arkhangelsk Pomors |
26.0 |
---|
Ch. Guangdong Meizhou H… |
25.8 |
---|
Pakistan Burusho |
25.5 |
---|
USA South Dakota Lakota S… |
24.4 |
---|
Russia Nenets |
23.8 |
---|
USA New Mexico Canoncito … |
23.2 |
---|
China South Han |
20.8 |
---|
Brazil Terena |
20.2 |
---|
China Guangzhou |
19.9 |
---|
USA Asian |
19.5 |
---|
Ireland Northern |
18.6 |
---|
Swiss Geneva |
18.2 |
---|
Taiwan Bunun |
17.8 |
---|
Ireland South |
17.4 |
---|
Singapore Javanese Indone… |
17.0 |
---|
Philippines Ivatan |
16.0 |
---|
Taiwan Rukai |
16.0 |
---|
Australia New South Wales |
15.8 |
---|
Finland |
15.6 |
---|
USA South Texas Hispanics |
15.6 |
---|
Pakistan Sindhi |
15.5 |
---|
United Kingdom Caucasians |
15.5 |
---|
Saudi Arabia Guraiat and … |
15.2 |
---|
Cameroon Pygmy Baka |
15.0 |
---|
India Tamil Nadu Nadar |
14.8 |
---|
Japan Central |
14.6 |
---|
Russia Murmansk Saomi |
14.0 |
---|
USA Hawaii Okinawa |
13.8 |
---|
China Beijing |
13.6 |
---|
China Tibetan |
13.3 |
---|
China Qinghai Hui |
13.2 |
---|
Thailand |
13.0 |
---|
USA North American Native… |
12.8 |
---|
China Inner Mongolia |
12.7 |
---|
Japan (3) |
12.7 |
---|
Pakistan Brahui |
12.5 |
---|
PNG Wanigela |
12.5 |
---|
USA Caucasian pop2 |
12.5 |
---|
USA Hispanic |
12.4 |
---|
Czech Republic |
12.3 |
---|
China North Han |
11.9 |
---|
Taiwan Paiwan |
11.8 |
---|
China Wuhan |
11.6 |
---|
Cameroon Sawa |
11.5 |
---|
Taiwan Siraya |
10.8 |
---|
Taiwan Ami |
10.7 |
---|
New Caledonia |
10.0 |
---|
India North Delhi |
9.9 |
---|
Australia Indig. Cape Yor… |
9.6 |
---|
Pakistan Pathan |
9.5 |
---|
France West |
9.4 |
---|
Iran Baloch |
9.4 |
---|
South Africa Natal Tamil |
9.4 |
---|
German Essen |
9.1 |
---|
Taiwan Puyuma |
9.0 |
---|
India New Delhi |
8.9 |
---|
Pakistan Kalash |
8.7 |
---|
India Mumbai Marathas |
8.6 |
---|
Russia Tuva pop 2 |
8.6 |
---|
South Korea (3) |
8.3 |
---|
American Samoa |
8.0 |
---|
Brazil |
8.0 |
---|
USA African American |
8.0 |
---|
France South East |
7.2 |
---|
Cameroon Bamileke |
7.1 |
---|
India West Bhils |
7.0 |
---|
Australia Indig. Yuendumu |
6.8 |
---|
Cameroon Beti |
6.6 |
---|
Georgia Tibilisi Georgian… |
6.5 |
---|
Uganda Kampala |
6.1 |
---|
Turkey |
6.0 |
---|
Spain Eastern Andalusia |
5.5 |
---|
PNG Wosera |
5.4 |
---|
Mali Bandiagara |
4.7 |
---|
Zimbabwe Harare Shona |
4.6 |
---|
Mexico Chihuahua State Ta… |
4.5 |
---|
Pakistan Baloch |
4.5 |
---|
Kenya |
4.4 |
---|
Zambia Lusaka |
4.4 |
---|
Lebanon |
4.1 |
---|
Israel Arab Druse |
4.0 |
---|
Kenya Luo |
3.8 |
---|
Tunisia |
3.6 |
---|
PNG Eastern Highlands Gor… |
3.5 |
---|
Sudanese |
3.5 |
---|
Georgia Tibilisi Kurds |
3.4 |
---|
Morocco 'Berber' Nador Me… |
3.2 |
---|
England London Ashkenazi … |
2.9 |
---|
|
---|
Allele frequencies presented, only |
References