HLA-Cw4
HLA-Cw4 (Cw4) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw4 is determined by the antibody recognition of α4 subset of HLA-Cw α-chains. For the serotype Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus.[1] Cw4 and Cw*04 are almost synonymous in meaning. Cw4 is more common in Southeast Europe, where it is part of the Cw4-B35 haplotype.
Serotype
Cw4 recognition of some HLA Cw*04 gene products[2]
| Cw*04 |
Cw4 |
Cw403 | Cw6 |
Sample |
| allele | % | % | % |
size (N) |
| *0401 | 98 | 0 | 0 | 736 |
| *0403 | 37 | 5 | 17 | 25 |
Alleles
HLA Cw*0401 frequencies| Study population |
Freq.
(in %)[3] |
|---|
|
|---|
| Mexico Mixe Oaxaca |
37.8 |
|---|
| Mexico Mixtec Oaxaca |
37.3 |
|---|
| USA N. Mexico Canoncito N… |
31.7 |
|---|
| Mexico Zaptotec Oaxaca |
30.6 |
|---|
| Iran Baloch |
28.6 |
|---|
| Australia Indig. Cape Yor… |
27.5 |
|---|
| Australia Indig.Yuendumu |
26.8 |
|---|
| Australia Indig. Groote E… |
25.3 |
|---|
| Lebanon |
24.3 |
|---|
| Israel Arab Druse |
22.5 |
|---|
| Georgia Tibilisi Kurds |
22.4 |
|---|
| Brazil Terena |
22.3 |
|---|
| Georgia Tibilisi Georgian… |
22.0 |
|---|
| India Tamil Nadu Nadar |
21.3 |
|---|
| Mali Bandiagara |
21.3 |
|---|
| Taiwan Ami |
20.9 |
|---|
| Papua New Guinea Wanigela |
20.8 |
|---|
| USA African Americans pop… |
19.6 |
|---|
| Senegal Niokholo Mandenka |
19.5 |
|---|
| Cameroon Beti |
18.7 |
|---|
| Indig. Australian Kimberl… |
17.9 |
|---|
| Papua New Guinea Wosera |
17.0 |
|---|
| Italy North pop 1 |
16.7 |
|---|
| New Caledonia |
16.7 |
|---|
| Morocco Nador Metalsa (be… |
15.9 |
|---|
| Portugal Centre pop 2 |
15.8 |
|---|
| Cameroon Sawa |
15.4 |
|---|
| India Mumbai Marathas |
15.4 |
|---|
| Iran Tehran |
15.4 |
|---|
| USA Hispanic |
15.0 |
|---|
| PNG West Schrader Ranges |
14.8 |
|---|
| Zimbabwe Harare Shona |
14.8 |
|---|
| Swiss Geneva |
14.5 |
|---|
| Zambia Lusaka |
14.4 |
|---|
| Uganda Kampala |
14.1 |
|---|
| Brazil |
13.7 |
|---|
| Sudanese |
13.5 |
|---|
| France West |
13.4 |
|---|
| Tibetan |
13.3 |
|---|
| Finland |
13.3 |
|---|
| Kenya Luo |
13.2 |
|---|
| Cameroon Bamileke |
13.0 |
|---|
| Philippines Ivatan |
13.0 |
|---|
| Kenya |
12.9 |
|---|
| Singapore Riau Malay |
12.2 |
|---|
| India North Delhi |
11.7 |
|---|
| Tunisia |
11.6 |
|---|
| Kenya Nandi |
11.5 |
|---|
| Russia Tuva pop 2 |
11.5 |
|---|
| Taiwan Bunun |
11.4 |
|---|
| USA Caucasian pop2 |
11.1 |
|---|
| India West Coast Parsis |
11.0 |
|---|
| China Qinghai Hui |
10.9 |
|---|
| Czech Republic |
10.8 |
|---|
| India New Delhi |
10.7 |
|---|
| Spain Eastern Andalusia |
10.4 |
|---|
| UK Caucasians |
10.1 |
|---|
| Cameroon Pygmy Baka |
10.0 |
|---|
| China Beijing |
10.0 |
|---|
| Jordan Amman |
10.0 |
|---|
| Singapore Javanese |
10.0 |
|---|
| Papua New Guinea Madang |
9.5 |
|---|
| Saudi Arabia Guraiat and … |
9.5 |
|---|
| Australia New South Wales |
9.4 |
|---|
| USA Alaska Yupik Natives |
9.3 |
|---|
| Bulgaria Gipsy |
9.1 |
|---|
| Mex. Chihuahua Tarahumara |
9.1 |
|---|
| German Essen |
9.0 |
|---|
| France South East |
8.9 |
|---|
| Taiwan Paiwan |
8.8 |
|---|
| China Inner Mongolia |
8.3 |
|---|
| Ireland Northern |
8.3 |
|---|
| Venezuela Perija Yucpa |
8.3 |
|---|
| South Korea (1) |
8.2 |
|---|
| China North Han |
7.6 |
|---|
| USA South Dakota Lakota S… |
7.4 |
|---|
| Taiwan Atayal |
7.1 |
|---|
| India West Bhils |
7.0 |
|---|
| PNG Karimui Plateau |
6.9 |
|---|
| Taiwan Siraya |
6.9 |
|---|
| Taiwan Thao |
6.7 |
|---|
| Japan (5) |
6.5 |
|---|
| Thailand |
6.0 |
|---|
| China Guangzhou |
5.6 |
|---|
| USA Asian |
5.6 |
|---|
| Ireland South |
5.4 |
|---|
| PNG Eastern Highlands Gor… |
4.7 |
|---|
| Japan Central |
4.6 |
|---|
| Spain Eastern Andalusia G… |
4.5 |
|---|
| China South Han |
4.4 |
|---|
| South Africa Natal Tamil |
4.2 |
|---|
| American Samoa |
4.0 |
|---|
| Taiwan Saisiat |
3.9 |
|---|
| Papua New Guinea New Brit… |
3.6 |
|---|
| Taiwan Minnan pop 1 |
3.4 |
|---|
| USA Hawaii Okinawa |
3.3 |
|---|
| China Guangdong Meizhou H… |
3.0 |
|---|
| India Khandesh Pawra |
3.0 |
|---|
| Taiwan Puyuma |
3.0 |
|---|
|
|
|---|
|
Allele frequencies presented, only |
HLA Cw*0403 frequencies| Study population |
Freq.
(in %)[3] |
|---|
|
|---|
| PNG West Schrader Ranges |
45.9 |
|---|
| Taiwan Tao |
40.0 |
|---|
| PMG Eastern Highlands Gor… |
34.9 |
|---|
| PNG Madang |
25.0 |
|---|
| PNG Wanigela |
16.0 |
|---|
| Australia Indig. Cape Yor… |
15.7 |
|---|
| Australia Indig. Yuendumu |
15.1 |
|---|
| Australia Indig. Groote E… |
12.3 |
|---|
| Taiwan Puyuma |
12.0 |
|---|
| PNG Karimui Plateau |
11.9 |
|---|
| Taiwan Pazeh |
11.8 |
|---|
| Taiwan Thao |
11.7 |
|---|
| New Caledonia |
11.1 |
|---|
| Singapore Riau Malay |
9.8 |
|---|
| PNG New Britain Rabaul |
8.9 |
|---|
| PNG Wosera |
8.0 |
|---|
| Singapore Javanese |
7.0 |
|---|
| Taiwan Rukai |
7.0 |
|---|
| Taiwan Bunun |
6.4 |
|---|
| American Samoa |
6.0 |
|---|
| Thailand |
5.3 |
|---|
| Philippines Ivatan |
5.0 |
|---|
| Taiwan Siraya |
4.9 |
|---|
| Taiwan Tsou |
4.9 |
|---|
| Australia Indig. Kimberly |
3.6 |
|---|
| Taiwan Atayal |
3.3 |
|---|
| South Africa Natal Tamil |
3.1 |
|---|
| Taiwan Ami |
2.6 |
|---|
| China South Han |
2.1 |
|---|
| USA Asian |
2.0 |
|---|
| Taiwan Hakka |
1.8 |
|---|
| China Qinghai Hui |
1.4 |
|---|
| Iran Tehran |
1.3 |
|---|
| China Guangdong Meizhou H… |
1.0 |
|---|
| China Inner Mongolia |
1.0 |
|---|
| India West Coast Parsis |
1.0 |
|---|
| Taiwan Minnan pop 1 |
1.0 |
|---|
| Taiwan Paiwan |
1.0 |
|---|
| India New Delhi |
0.9 |
|---|
| Russia Tuva |
0.9 |
|---|
| China Tibetan |
0.6 |
|---|
|
|
|---|
|
Allele frequencies presented, only |
References
