HLA-B18

major histocompatibility complex (human), class I, B18
Alleles B*1801
Alleles B*1802
Alleles B*1803
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*1801
EBI-HLA B*1802
EBI-HLA B*1803
Locus chr.6 6p21.31

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products.[1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

Serotype

B18 serotype recognition of Some HLA B*18 allele-group gene products[2]
B*18 B18 Sample
allele % % size (N)
1801 96 1641
1802 90 31
1803 83 29

Allele frequencies

HLA B*1801 frequencies
freq
ref. Population (%)
[3] Italy North pop 116.7
[3] Croatia11.3
[3] Georgia Svaneti Svans11.3
[3] Romanian11.3
[3] Portugal South11.2
[3] Singapore Riau Malay9.9
[3] Bulgaria9.1
[3] Israel Arab Druse8.5
[3] Azores Central Islands8.0
[3] Portugal Centre8.0
[3] Finland7.8
[3] Azores Santa Maria and Sao Miguel7.7
[3] Czech Republic7.5
[3] India Jalpaiguri Toto7.5
[3] Iran Baloch7.1
[3] Philippines Ivatan7.0
[3] Thailand6.7
[3] Tunisia6.7
[3] Portugal North6.5
[3] Zimbabwe Harare Shona6.4
[3] Madeira6.2
[3] Mexico Mestizos6.1
[3] Kenya 5.9
[3] Belgium5.1
[3] Morocco Nador Metalsa Class I5.1
[3] Singapore Javanese Indonesians5.1
[3] Israel Ashkenazi and Non Ashkenazi Jews5.0
[3] Uganda Kampala5.0
[3] Kenya Nandi4.8
[3] Oman4.7
[3] Georgia Tibilisi Georgians4.6
[3] Bulgaria Gipsy4.5
[3] France South East4.3
[3] Kenya Luo4.3
[3] Ireland South4.2
[3] Russia Arkhangelsk Pomors4.0
[3] Azores Terceira Island3.9
[3] Guinea Bissau3.8
[3] India New Delhi3.8
[3] Spain Eastern Andalusia Gipsy3.5
[3] Australia New South Wales3.4
[3] Georgia Tibilisi Kurds3.4
[3] Zambia Lusaka3.4
[3] Cameroon Yaounde2.7
[3] Senegal Niokholo Mandenka2.7
[3] Cameroon Beti2.3
[3] Ivory Coast Akan Adiopodoume2.3
[3] Sudanese2.3
[3] Saudi Arabia Guraiat and Hail2.2
[3] South African Natal Zulu2.0
[3] Thailand2.0
[3] India Mumbai Marathas1.9
[3] New Caledonia1.9
[3] Papua New Guinea Wanigela1.5
[3] Cameroon Bamileke1.3

References

  1. ↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. PMID 15787720. doi:10.1111/j.1399-0039.2005.00379.x.
  2. ↑ derived from IMGT/HLA
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. doi:10.1034/j.1399-0039.2003.00062.x. External link in |title= (help)
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