HLA-A80

HLA-A80
(MHC Class I, A cell surface antigen)

HLA-A80
About
Protein transmembrane receptor/ligand
Structure αβ heterodimer
Subunits HLA-A*8001, β2-microglobulin
Older names AX"BG"
Subtypes
Subtype
allele
Available structures
A*80 *8001
{{{cNick2}}} *80{{{cAllele2}}}
{{{cNick3}}} *80{{{cAllele3}}}
{{{cNick4}}} *80{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A80 (A80) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α80 subset of HLA-A α-chains. For A80, the alpha "A" chain are encoded by the HLA-A*80 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*8001. A80 and A*80 are almost synonymous in meaning.

Further information: History and naming of human leukocyte antigens

A80 is more common in West Central Africa. A80 is the least common HLA-A allele group.

Serotype

A80 recognition of some HLA A*80 gene products[2]
A*80 A80 A10 Sample
allele % % size (N)
*8001 36 10 505

A80 HLA-A80 typing is poor. Most typing is done with SSP-PCR. Most of 8001 are detected with "Blank" serotype..

Distribution

HLA A*8001 frequencies
Study population Freq.
 (in %)[3]
Senegal Niokholo Mandenka 3.8
Zambia Lusaka 2.3
Cameroon Bamileke 1.9
Mali Bandiagara 1.5
South Africa Tswana 1.2
Spain Minorca 1.1
Cameroon Bakola Pygmy 1.0
Burkina Faso Fulani 1.0
Trinidad Africans 1.0
Tunisia 1.0
Bulgaria 0.9
Cape Verde Southeastern I… 0.8
Guinea Bissau 0.8
USA African Americans 0.8
Peru Arequipa 0.7
Turkey class I 0.7
Cameroon Beti 0.6
Spain Catalonia Girona 0.6
USA Caucasians (3) 0.6
Brazil 0.5
Brazil Belo Horizonte 0.5
Brazil Pernambuco State 0.5
Croatia pop2 0.5
Guatemala Mayans 0.4
Mongolia Buriat 0.4
Allele frequencies presented, only

Further reading

References

  1. ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. PMID 77067. doi:10.1111/j.1399-0039.1978.tb01233.x.
  2. ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. ↑ Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. doi:10.1034/j.1399-0039.2003.00062.x.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.