HLA-A74

HLA-A74
(MHC Class I, A cell surface antigen)
HLA-A74
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*74--, β2-microglobulin
Subtypes
Subtype allele Available structures A74 *7401 {{{cNick2}}} *74{{{cAllele2}}} {{{cNick3}}} *74{{{cAllele3}}} {{{cNick4}}} *74{{{cAllele4}}}
Rare alleles
Subtype allele Available structures A74.3 *7403 {{{rnick2}}} *74{{{rallele2}}} {{{rnick3}}} *74{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁷⁴ subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A*74 allele group and the β-chain are encoded by B2M locus.^[1] A74 and A*74 are almost synonymous in meaning. A74 is a split antigen of the broad antigen serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33.

A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.

Serotype

A74 has a poor serotyping rate.

Disease associations

A significant association has been found between A74 and nasal polyposis.^[3]

Allele distribution

Sources

• Madrigal JA, Belich MP, Hildebrand WH, et al. (November 1992). "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion" (PDF). J. Immunol. 149 (10): 3411–5. PMID 1431115. 

References