HLA-A29

HLA-A29
(MHC Class I, A cell surface antigen)

HLA-A29
About
Protein transmembrane receptor/ligand
Structure αβ heterodimer
Subunits HLA-A*29--, β2-microglobulin
Older names A19
Subtypes
Subtype
allele
Available structures
A29.1 *2901
A29.2 *2902
{{{cNick3}}} *29{{{cAllele3}}}
{{{cNick4}}} *29{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A29 (A29) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α29 subset of HLA-A α-chains. For A29, the alpha "A" chain are encoded by the HLA-A*29 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2902. A29 and A*29 are almost synonymous in meaning. A29 is a split antigen of the broad antigen serotype A19. A29 is a sister serotype of A30, A31, A32, A33, and A74.

Further information: History and naming of human leukocyte antigens

A29 is more common in Western Africa and Southwestern Europe.

Serotype

A29 recognition of some HLA A*29 gene products[2]
A*29 A29 Sample
allele % size (N)
*2901 96  119
*2902 99 1148

Allele distribution

HLA A*2902 frequencies
Study population Freq.
 (in %)[3]
Spain Pas Valley 13.5
Spain Basque Gipuzkoa Pro… 12.5
South Africa Tswana 12.2
South African Natal Zulu 11.0
Cameroon Yaounde 10.4
Cameroon Pygmy Baka 10.0
Zimbabwe Harare Shona 9.6
Burkina Faso Fulani 9.5
Spain Catalonia Girona 9.3
Spain Ibizans 9.3
Tunisia Ghannouch 9.1
Saudi Arabia 8.7
Cameroon Bamileke 8.4
Cameroon Bakola Pygmy 8.3
Spain Murcia 8.3
Spain Minorca 8.2
Spain Basque Arratia Vall… 8.0
Cameroon Sawa 7.7
Spain North Cabuernigo 7.7
Tunisia 7.2
Portugal Centre 7.0
Spain Eastern Andalusia 6.9
Tunisia 6.7
Cameroon Beti 6.3
France Corsica 6.0
Scotland Orkney 6.0
Spain North Cantabrian 6.0
Zambia Lusaka 5.8
Kenya Luo 5.3
England Liverpool 5.2
France South East 5.1
Ireland Northern 4.9
Kenya 4.9
Tunisia Tunis 4.9
USA Hispanic 4.9
Kenya Nandi 4.8
Mongolia Hoton 4.8
Mongolia Khoton Tarialan 4.8
England Manchester 4.8
England Newcastle 4.7
Pakistan Karachi Parsi 4.4
USA Caucasian (2) 4.3
Morocco 'berber' Nador Me… 4.1
Israeli Jews 3.9
England Lancaster 3.8
India Jalpaiguri Toto 3.8
Senegal Niokholo Mandenka 3.8
Belgium 3.7
Italy 3.6
Wales 3.6
Morocco 3.4
Mali Bandiagara 3.3
Ireland South 3.2
Uganda Kampala 3.1
Australia New South Wales 3.0
Brazil 3.0
Macedonia (4) 3.0
China Yunnan Han (2) 2.9
Greece (3) 2.9
India North Delhi 2.7
Peru Arequipa 2.7
Taiwan Hakka 2.7
USA North American Native… 2.7
Italy South Campania 2.6
Italy Bergamo 2.6
Algeria1 2.5
India Kerala Hindu Nair 2.4
Israel Gaza Palestinians 2.4
Mexico Mestizos 2.4
Guatemala Mayans 2.3
German Essen 2.0
India West Coast Parsis 2.0
Israel Arab Druse 2.0
Romanian 1.9
Sudanese 1.8
Pakistan Brahui 1.7
Thailand Northeast 1.6
China Harbin Man 1.5
Guinea Bissau 1.5
Italy Sardinia pop3 1.5
Mexico Sonora Seri 1.5
Pakistan Pathan 1.5
Turkey 1.3
Czech Republic 1.4
Sweden Stockholm 1.4
Oman 1.3
Sweden Uppsala County 1.2
Russia Nenets 1.2
Allele frequencies presented, only
HLA A*2901 frequencies
Study population Freq.
 (in %)[3]
Georgia Tibilisi Kurds 6.7
Mexico Guadalajara Mestiz… 6.3
CAR Mbenzele Pygmy 5.7
Israel Arab Druse 4.5
Pakistan Karachi Parsi 4.4
Iran Baloch 2.8
Taiwan Hakka 2.7
Kenya 2.1
Saudi Arabia Guraiat and … 2.1
India West Coast Parsis 2.0
India North Hindus 1.9
Jordan Amman 1.7
Pakistan Brahui 1.7
China Guangzhou 1.5
India New Delhi 1.5
Pakistan Pathan 1.5
Singapore Thai 1.5
South African Natal Zulu 1.5
Georgia Svaneti Svans 1.3
Kenya Nandi 1.3
USA Asian 1.3
China South Han 1.2
Finland 1.1
India North Delhi 1.1
Kenya Luo 1.1
China Inner Mongolia 1.0
Portugal Centre 1.0
South Korea (3) 1.0
Pakistan Baloch 0.8
Croatia 0.7
Thailand 0.7
Ireland South 0.6
Romanian 0.6
Uganda Kampala 0.6
USA San Antonio Caucasian… 0.6
Allele frequencies presented, only

Haplotypes

For A29-Cw*16-B44 (A*2902:Cw*1601:B*4403) haplotype see Cw*16

References

  1. ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. PMID 77067. doi:10.1111/j.1399-0039.1978.tb01233.x.
  2. ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. 1 2 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. PMID 12753660. doi:10.1034/j.1399-0039.2003.00062.x.
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