Hes family bhlh transcription factor 2

HES2

Identifiers

HES2, bHLHb40, hes family bHLH transcription factor 2

External IDs

MGI: 1098624 HomoloGene: 22455 GeneCards: HES2

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	6,412,418 bp^[1]
Band	No data available	End	6,424,670 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	No data available	Start	152,158,867 bp^[2]
Band	No data available	End	152,162,469 bp^[2]

Gene ontology
Molecular function	• DNA binding • double-stranded DNA binding • transcription factor binding • protein dimerization activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Cellular component	• nucleus
Biological process	• negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


54626


15206


ENSG00000069812


ENSMUSG00000028940


Q9Y543


O54792

RefSeq (mRNA)


NM_019089


NM_001301805 NM_008236

RefSeq (protein)


NP_061962


NP_001288734 NP_032262

Location (UCSC)

Chr 1: 6.41 – 6.42 Mb

Chr 4: 152.16 – 152.16 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Hes family bHLH transcription factor 2 is a protein that in humans is encoded by the HES2 gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000069812 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028940 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Hes family bHLH transcription factor 2".

Further reading

Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. PMID 9570950. doi:10.1006/geno.1998.5213.
Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. PMID 15254753. doi:10.3892/ijo.25.2.529.
Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. PMID 17611704.

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