HERC1

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4O2W, 4QT6

Identifiers

Aliases

HERC1, p532, p619, HECT and RLD domain containing E3 ubiquitin protein ligase family member 1, MDFPMR

External IDs

MGI: 2384589 HomoloGene: 31207 GeneCards: HERC1

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	No data available	Start	63,608,618 bp^[1]
Band	No data available	End	63,833,942 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	No data available	Start	66,350,450 bp^[2]
Band	No data available	End	66,508,775 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • guanyl-nucleotide exchange factor activity • ARF guanyl-nucleotide exchange factor activity • transferase activity
Cellular component	• cytoplasm • cytosol • Golgi apparatus • membrane
Biological process	• cerebellar Purkinje cell differentiation • negative regulation of autophagy • neuron projection development • protein ubiquitination • neuromuscular process controlling balance • positive regulation of GTPase activity • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8925


235439

Ensembl


ENSG00000103657


ENSMUSG00000038664

UniProt


Q15751


n/a

RefSeq (mRNA)


NM_003922


NM_145617

RefSeq (protein)


NP_003913


n/a

Location (UCSC)

Chr 15: 63.61 – 63.83 Mb

Chr 9: 66.35 – 66.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable E3 ubiquitin-protein ligase HERC1 is an enzyme that in humans is encoded by the HERC1 gene.^[5]^[6]^[7]

The protein encoded by this gene stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein is thought to be involved in membrane transport processes^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000103657 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038664 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M (Dec 1996). "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins". EMBO J. 15 (16): 4262–73. PMC 452152 . PMID 8861955.
↑ Rosa JL, Barbacid M (Aug 1997). "A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70". Oncogene. 15 (1): 1–6. PMID 9233772. doi:10.1038/sj.onc.1201170.
1 2 "Entrez Gene: HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Garcia-Gonzalo FR, Bartrons R, Ventura F, Rosa JL (2005). "Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins". FEBS Lett. 579 (2): 343–8. PMID 15642342. doi:10.1016/j.febslet.2004.11.095.
Garcia-Gonzalo FR, Muñoz P, González E, et al. (2004). "The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells". FEBS Lett. 559 (1–3): 77–83. PMID 14960311. doi:10.1016/S0014-5793(04)00030-4.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Garcia-Gonzalo FR, Cruz C, Muñoz P, et al. (2003). "Interaction between HERC1 and M2-type pyruvate kinase". FEBS Lett. 539 (1–3): 78–84. PMID 12650930. doi:10.1016/S0014-5793(03)00205-9.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Cruz C, Paladugu A, Ventura F, et al. (1999). "Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 86 (1): 68–9. PMID 10516438. doi:10.1159/000015414.
Ji Y, Walkowicz MJ, Buiting K, et al. (1999). "The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities". Hum. Mol. Genet. 8 (3): 533–42. PMID 9949213. doi:10.1093/hmg/8.3.533.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

HERC1

References

Further reading