DEFA6

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1ZMQ, 3QTE

Identifiers

Aliases

DEFA6, DEF6, HD-6, defensin alpha 6

External IDs

HomoloGene: 130499 GeneCards: DEFA6

Gene ontology
Molecular function	• protein binding • protein homodimerization activity
Cellular component	• Golgi lumen • extracellular region • extracellular space
Biological process	• defense response • defense response to bacterium • defense response to fungus • antimicrobial humoral response • killing of cells of other organism • antimicrobial humoral immune response mediated by antimicrobial peptide
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1671


n/a

Ensembl


ENSG00000164822


n/a

UniProt


Q01524


n/a

RefSeq (mRNA)


NM_001926


n/a

RefSeq (protein)


NP_001917


n/a

Location (UCSC)

Chr 8: 6.92 – 6.93 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the DEFA6 gene.^[2]^[3] DEFA6 is expressed in the Paneth cells of the ileum.^[4]

Function

The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. HD6 has poor antibacterial potency.^[5] However, HD6 affords protection against invasion by enteric bacterial pathogens by self-assembly to form fibrils and nanonets that surround and entangle bacteria.^[6]

Several alpha defensin genes, including DEFA6, are clustered on chromosome 8.^[2]

References

↑ "Human PubMed Reference:".
1 2 "Entrez Gene: DEFA6 defensin, alpha 6, Paneth cell-specific (Homo sapiens)".
↑ Jones DE, Bevins CL (January 1993). "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel". FEBS Lett. 315 (2): 187–92. PMID 8417977. doi:10.1016/0014-5793(93)81160-2.
↑ Zhao C, Wang I, Lehrer RI (24 Nov 1996). "Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells". FEBS Lett. 396 (2–3): 319–22. PMID 8915011. doi:10.1016/0014-5793(96)01123-4.
↑ Ericksen B, Wu Z, Lu W, Lehrer RI (2005). "Antibacterial Activity and Specificity of the Six Human α-Defensins". Antimicrob Agents Chemother. 49 (1): 269–75. PMC 538877 . PMID 15616305. doi:10.1128/AAC.49.1.269-275.2005.
↑ Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL (2012). "Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets". Science. 337 (6093): 477–81. PMC 4332406 . PMID 22722251. doi:10.1126/science.1218831.

DEFA6

Function

References

Further reading