H2AFV

H2AFV

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3WAA

Identifiers

H2AFV, H2A.Z-2, H2AV, H2A histone family member V

External IDs

MGI: 1924855 HomoloGene: 83271 GeneCards: H2AFV

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	No data available	Start	44,826,791 bp^[1]
Band	No data available	End	44,848,083 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	6,427,229 bp^[2]
Band	No data available	End	6,444,443 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • protein heterodimerization activity
Cellular component	• nuclear chromatin • nucleosome • extracellular exosome • nucleus • chromosome
Biological process	• chromatin silencing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


94239


77605


ENSG00000105968


ENSMUSG00000041126


Q71UI9


Q3THW5

RefSeq (mRNA)


NM_201517 NM_012412 NM_138635 NM_201436 NM_201516


NM_029938 NM_001347064

RefSeq (protein)


NP_036544 NP_619541 NP_958844 NP_958924 NP_958925


NP_001333993 NP_084214

Location (UCSC)

Chr 7: 44.83 – 44.85 Mb

Chr 11: 6.43 – 6.44 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.^[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcripts have been identified for this gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105968 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041126 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: H2AFV H2A histone family, member V".

Further reading

El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. PMC 110633 . PMID 9566873. doi:10.1128/mcb.18.5.2535.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–295. PMID 11080476. doi:10.1006/viro.2000.0593.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–326. PMID 11689053. doi:10.1006/viro.2001.1129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. PMID 12853948. doi:10.1038/nature01782.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–6561. PMC 291826 . PMID 14657027. doi:10.1093/emboj/cdg631.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–954. PMID 16341674. doi:10.1007/s00335-005-0075-2.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Boyne MT, Pesavento JJ, Mizzen CA, Kelleher NL (2006). "Precise characterization of human histones in the H2A gene family by top down mass spectrometry". J. Proteome Res. 5 (2): 248–253. PMID 16457589. doi:10.1021/pr050269n.
Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–618. PMID 16916647. doi:10.1016/j.molcel.2006.06.026.

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