Glycinamide hydrochloride

Glycinamide hydrochloride

Names
IUPAC name 2-aminoacetamide:hydrochloride[1]
Other names Glycinamide hydrochloride
Identifiers
CAS Number	1668-10-6
EC Number	216-789-1
PubChem CID	2723639
InChI Key: WKNMKGVLOWGGOU-UHFFFAOYSA-N
Properties
Chemical formula	C2H7ClN2O
Molar mass	110.541 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Glycinamide hydrochloride is one of Good's buffers with a pH in the physiological range and is a reagent used in the synthesis of glycineamide ribonucleotide (an intermediate in de novo purine biosynthesis)^[2], [M(glycinamidato-N,N')(ptpy)₂] where ptpy = 2-(p-tolyl)pyridinato) and M = Rh or Ir,^[3] and the following glycinamide-based imidazolidinones:^[4]

• (±)-2-(2-phenylpropyl)imidazolidin-4-one
• (±)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one
• (±)-2-[(R)-2,6-dimethyl-5-heptenyl]imidazolidin-4-one
• (5R,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
• (5S,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
• (±)-2-methyl-2-pentylimidazolidin-4-one
• (±)-2-ethyl-2-(2-methylbutyl)imidazolidin-4-one
• (±)-2-(undecan-2-yl)imidazolidin-4-one
• (±)-2-pentylimidazolidin-4-one
• 2-(2,4-dimethylcyclohex-3-en-1-yl)imidazolidin-4-one

Glycinamide hydrochloride has a pKa near the physiological pH (8.20 at 20°C), making it useful in cell culture work. Its ΔpKa/°C is -0.029 and it has a solubility in water at 0°C of 6.4M.

References