Gisela Mosig
| Gisela Mosig | |
|---|---|
| Born |
November 29, 1930 Saxony, Germany |
| Died |
January 12, 2003 (aged 72) Nashville, Tennessee, U.S. |
| Nationality |
Germany United States |
| Fields | Molecular genetics |
| Known for | Molecular biology of enterobacteria phage T4 |
Gisela Mosig (November 29, 1930 – January 12, 2003) was a molecular biologist best known for her work with enterobacteria phage T4.[1][2] She was among the first investigators to recognize the importance of recombination intermediates in establishing new DNA replication forks, a fundamental process in DNA replication.[3][1]
Early years
While growing up on a farm in Saxony, Mosig became interested in biology and physics.[2][1] After World War II (when she was 14 years old), the region where she lived became part of East Germany and evolutionary teaching in her high school skewed toward Lysenkoism.[1] Finding the intellectual atmosphere intolerable, she fled to the west on her bicycle with only the belongings she could carry.[2]
After undergraduate studies at the University of Bonn, she earned her doctoral degree in plant genetics at the University of Cologne in 1959.[2]
From there, she was recruited to Vanderbilt University to study bacteriophage T4, a topic for which she became a leading investigator.[1] After postdoctoral research at Vanderbilt and then the Carnegie Institute of Washington at Cold Spring Harbor (with Nobel laureate A. D. Hershey), she returned to Vanderbilt as a faculty member in 1965, and became a citizen of the United States of America in 1968.[1]
Recognition
- Outstanding Graduate Teaching Award (Vanderbilt, 1989)[4]
- Elected Fellow of the American Academy of Microbiology (1994)[1]
- Earl Sutherland Prize for Achievement in Research (Vanderbilt, 1995)[5][2]
Death
Mosig died at Alive Hospice in Nashville a few years after being diagnosed with metastatic ovarian cancer; she was 72 years old.[1][2]
Key publications
- Mosig, G (June 1968). "A map of distances along the DNA molecule of phage T4.". Genetics. 59 (2): 137–51. PMC 1211937
. PMID 5702346. - Luder, A; Mosig, G (February 1982). "Two alternative mechanisms for initiation of DNA replication forks in bacteriophage T4: priming by RNA polymerase and by recombination.". Proceedings of the National Academy of Sciences of the United States of America. 79 (4): 1101–5. PMC 345908 . PMID 7041114. doi:10.1073/pnas.79.4.1101.
- Mathews, Christoper K.; Kutter, Elizabeth M.; Mosig, Gisela; Berget, Peter B. (1983). Bacteriophage T4. Washington, D.C.: American Soc. for Microbiology. ISBN 0914826565.
- Mosig, G (1987). "The essential role of recombination in phage T4 growth". Annual Review of Genetics. 21: 347–71. PMID 3327469. doi:10.1146/annurev.ge.21.120187.002023.
- Mosig, G (1998). "Recombination and recombination-dependent DNA replication in bacteriophage T4". Annual Review of Genetics. 32: 379–413. PMID 9928485. doi:10.1146/annurev.genet.32.1.379.
- Miller, ES; Kutter, E; Mosig, G; Arisaka, F; Kunisawa, T; Rüger, W (March 2003). "Bacteriophage T4 genome". Microbiology and molecular biology reviews: MMBR. 67 (1): 86–156. PMC 150520 . PMID 12626685. doi:10.1128/mmbr.67.1.86-156.2003.
References
- 1 2 3 4 5 6 7 8 Nossal, NG; Franklin, JL; Kutter, E; Drake, JW (November 2004). "Gisela Mosig.". Genetics. Anecdotal, historical and critical commentaries on genetics. 168 (3): 1097–104. PMC 1448779 . PMID 15579671.
- 1 2 3 4 5 6 "Pioneering genetic researcher Gisela Mosig dies (01/24/03)". Vanderbilt Reporter. Vanderbilt University Medical Center. Retrieved January 16, 2017.
- ↑ Syeda, Aisha H.; Hawkins, Michelle; McGlynn, Peter (2014-10-23). "Recombination and replication". Cold Spring Harbor Perspectives in Biology. 6 (11): a016550. ISSN 1943-0264. PMC 4413237 . PMID 25341919. doi:10.1101/cshperspect.a016550.
- ↑ "Faculty and Graduate Student Awards". Faculty and Graduate Student Awards. Vanderbilt University. Retrieved 16 January 2017.
- ↑ "Earl Sutherland Prize for Achievement in Research". www.vanderbilt.edu. lt University Office of the Provost. Retrieved January 17, 2017.