Giantin

GOLGB1

Identifiers

GOLGB1, GCP, GCP372, GOLIM1, golgin B1

External IDs

MGI: 1099447 HomoloGene: 68401 GeneCards: GOLGB1

Gene ontology
Molecular function	• protein binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • RNA binding
Cellular component	• integral component of membrane • Golgi membrane • Golgi stack • cis-Golgi network • Golgi apparatus • membrane • endoplasmic reticulum-Golgi intermediate compartment
Biological process	• ER to Golgi vesicle-mediated transport • Golgi organization • regulation of transcription, DNA-templated • protein localization to pericentriolar material
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2804


224139

Ensembl


ENSG00000173230


ENSMUSG00000034243

UniProt


Q14789


n/a

RefSeq (mRNA)


NM_001256486 NM_001256487 NM_001256488 NM_004487


NM_030035

RefSeq (protein)


NP_001243415 NP_001243416 NP_001243417 NP_004478


n/a

Location (UCSC)

Chr 3: 121.66 – 121.75 Mb

Chr 16: 36.88 – 36.93 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene.^[3]^[4]^[5] Giantin is a disulfide-linked homodimer.

Interactions

GOLGB1 has been shown to interact with ACBD3 and with PLK3.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Linstedt AD, Hauri HP (Nov 1993). "Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa". Mol Biol Cell. 4 (7): 679–93. PMC 300978 . PMID 7691276. doi:10.1091/mbc.4.7.679.
↑ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell. 15 (5): 2423–35. PMC 404034 . PMID 15004235. doi:10.1091/mbc.E03-09-0699.
↑ "Entrez Gene: GOLGB1 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1".
↑ Sohda, M; Misumi Y; Yamamoto A; Yano A; Nakamura N; Ikehara Y (Nov 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. United States. 276 (48): 45298–306. ISSN 0021-9258. PMID 11590181. doi:10.1074/jbc.M108961200.

Sohda M, Misumi Y, Fujiwara T, et al. (1995). "Molecular cloning and sequence analysis of a human 372-kDA protein localized in the Golgi complex.". Biochem. Biophys. Res. Commun. 205 (2): 1399–408. PMID 7802676. doi:10.1006/bbrc.1994.2821.
Seelig HP, Schranz P, Schröter H, et al. (1994). "Macrogolgin--a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections.". J. Autoimmun. 7 (1): 67–91. PMID 8198703. doi:10.1006/jaut.1994.1006.
Sönnichsen B, Lowe M, Levine T, et al. (1998). "A role for giantin in docking COPI vesicles to Golgi membranes.". J. Cell Biol. 140 (5): 1013–21. PMC 2132694 . PMID 9490716. doi:10.1083/jcb.140.5.1013.
Linstedt AD, Jesch SA, Mehta A, et al. (2000). "Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus.". J. Biol. Chem. 275 (14): 10196–201. PMID 10744704. doi:10.1074/jbc.275.14.10196.
Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G (2000). "Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments.". J. Cell Biol. 150 (3): 475–88. PMC 2175190 . PMID 10931861. doi:10.1083/jcb.150.3.475.
Alvarez C, Garcia-Mata R, Hauri HP, Sztul E (2001). "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic.". J. Biol. Chem. 276 (4): 2693–700. PMID 11035033. doi:10.1074/jbc.M007957200.
Sohda M, Misumi Y, Yamamoto A, et al. (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin.". J. Biol. Chem. 276 (48): 45298–306. PMID 11590181. doi:10.1074/jbc.M108961200.
Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.". J. Cell Biol. 157 (1): 45–62. PMC 2173270 . PMID 11927603. doi:10.1083/jcb.200112127.
Gillingham AK, Pfeifer AC, Munro S (2003). "CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.". Mol. Biol. Cell. 13 (11): 3761–74. PMC 133590 . PMID 12429822. doi:10.1091/mbc.E02-06-0349.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics. 3 (4): 311–26. PMID 14718574. doi:10.1074/mcp.M300127-MCP200.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242–53. PMID 15308636. doi:10.1074/jbc.M406644200.
Malsam J, Satoh A, Pelletier L, Warren G (2005). "Golgin tethers define subpopulations of COPI vesicles.". Science. 307 (5712): 1095–8. PMID 15718469. doi:10.1126/science.1108061.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell. 122 (6): 957–68. PMID 16169070. doi:10.1016/j.cell.2005.08.029.
Rosing M, Ossendorf E, Rak A, Barnekow A (2007). "Giantin interacts with both the small GTPase Rab6 and Rab1.". Exp. Cell Res. 313 (11): 2318–25. PMID 17475246. doi:10.1016/j.yexcr.2007.03.031.

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Giantin

Interactions

References

Further reading