Gallamine triethiodide
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| Trade names | Flaxedil |
| AHFS/Drugs.com | International Drug Names |
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| ECHA InfoCard | 100.000.550 |
| Chemical and physical data | |
| Formula |
C30H60N3O3+3 · 3 I− (gallamine triethiodide) C24H45N3O3 (gallamine) |
| Molar mass |
891.529 g/mol (gallamine triethiodide) 423.633 g/mol (gallamine) |
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Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.[2] Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia[3][4] and occasionally hypertension. Very high doses cause histamine release.
Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.
It was developed by Daniel Bovet in 1947.[5]
The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.
An ampoule of gallamine.
References
- ↑ "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.
- ↑ "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.
- ↑ Morgenstern C, Splith G (October 1965). "[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics]". Der Anaesthesist (in German). 14 (10): 298–301. PMID 4380161.
- ↑ WALTS LF (1963). "Ventricular tachycardia with gallamine and cyclopropane anesthesia". Anesthesiology. 24: 119. PMID 13998750. doi:10.1097/00000542-196301000-00024. Retrieved 2014-09-20.
- ↑ Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med. 95 (7): 363–7. PMC 1279945
. PMID 12091515. doi:10.1258/jrsm.95.7.363.
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