GZMB

GZMB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1FQ3, 1IAU
Identifiers
Aliases	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs	HomoloGene: 108184 GeneCards: GZMB
Gene ontology Molecular function • peptidase activity • protein binding • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cellular component • cytosol • membrane • immunological synapse • nucleus • mitochondrion • secretory granule Biological process • cytolysis • proteolysis • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • natural killer cell mediated cytotoxicity • apoptotic process • granzyme-mediated apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3002	n/a
Ensembl	ENSG00000100453	n/a
UniProt	P10144	n/a
RefSeq (mRNA)	NM_004131 NM_001346011	n/a
RefSeq (protein)	NP_001332940 NP_004122	n/a
Location (UCSC)	Chr 14: 24.63 – 24.63 Mb	n/a
PubMed search	[1]	n/a
Wikidata
View/Edit Human

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.^[2] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.^[3]

See also

• The Proteolysis Map
• Granzyme

References

Further reading

External links

• The MEROPS online database for peptidases and their inhibitors: S01.010

PDB gallery
1fq3: CRYSTAL STRUCTURE OF HUMAN GRANZYME B  1iau: HUMAN GRANZYME B IN COMPLEX WITH AC-IEPD-CHO