GSG2

HASPIN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC, 4QTC, 5HTC, 5HTB

Identifiers

HASPIN, GSG2, germ cell associated 2, haspin, histone H3 associated protein kinase

External IDs

MGI: 1194498 HomoloGene: 49236 GeneCards: HASPIN

Gene ontology
Molecular function	• transferase activity • nucleotide binding • kinase activity • protein serine/threonine kinase activity • protein binding • histone kinase activity (H3-T3 specific) • ATP binding • protein kinase activity
Cellular component	• cytoplasm • centrosome • chromosome • cytoskeleton • nucleus • spindle
Biological process	• intracellular signal transduction • phosphorylation • histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore • mitotic sister chromatid cohesion • regulation of spindle checkpoint • protein localization to chromosome, centromeric region • cell cycle • protein phosphorylation • covalent chromatin modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


83903


14841


ENSG00000177602


ENSMUSG00000050107


Q8TF76


Q9Z0R0

RefSeq (mRNA)


NM_031965


NM_010353

RefSeq (protein)


NP_114171


NP_034483

Location (UCSC)

Chr 17: 3.72 – 3.73 Mb

Chr 11: 73.14 – 73.14 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.^[3]

References

Further reading

Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B.". Dev. Cell. 11 (5): 741–50. PMID 17084365. doi:10.1016/j.devcel.2006.09.018.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. PMC 1459365 . PMID 16565220. doi:10.1073/pnas.0507066103.
Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.". Genes Dev. 19 (4): 472–88. PMC 548948 . PMID 15681610. doi:10.1101/gad.1267105.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells.". Gene. 267 (1): 55–69. PMID 11311556. doi:10.1016/S0378-1119(01)00387-0.
Tanaka H, Iguchi N, Nakamura Y, et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase.". Mol. Hum. Reprod. 7 (3): 211–8. PMID 11228240. doi:10.1093/molehr/7.3.211.

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