GRAP

GRAP
Identifiers
AliasesGRAP, GRB2-related adaptor protein
External IDsMGI: 1918770 HomoloGene: 4822 GeneCards: GRAP
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10750

71520

Ensembl

ENSG00000154016

ENSMUSG00000004837

UniProt

Q13588

Q9CX99

RefSeq (mRNA)

NM_006613
NM_001330148

NM_027817

RefSeq (protein)

NP_001317077
NP_006604

NP_082093

Location (UCSC)Chr 17: 19.02 – 19.05 MbChr 11: 61.65 – 61.67 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene.[3][4][5]

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.[5]

Interactions

GRAP has been shown to interact with Linker of activated T cells.[6][7]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". The Journal of Biological Chemistry. 271 (21): 12129–32. PMID 8647802. doi:10.1074/jbc.271.21.12129.
  4. ↑ Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Jan 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". The Journal of Biological Chemistry. 272 (2): 894–902. PMID 8995379. doi:10.1074/jbc.272.2.894.
  5. 1 2 "Entrez Gene: GRAP GRB2-related adaptor protein".
  6. ↑ Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell. 92 (1): 83–92. PMID 9489702. doi:10.1016/S0092-8674(00)80901-0.
  7. ↑ Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40. PMID 12186560. doi:10.1021/bi025554o.

Further reading

  • Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene. 16 (7): 891–901. PMID 9484780. doi:10.1038/sj.onc.1201607. 
  • Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell. 92 (1): 83–92. PMID 9489702. doi:10.1016/S0092-8674(00)80901-0. 
  • Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (Dec 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Letters. 509 (2): 255–62. PMID 11741599. doi:10.1016/S0014-5793(01)03174-X. 
  • Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (Sep 2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". The Journal of Biological Chemistry. 278 (36): 34641–53. PMID 12819203. doi:10.1074/jbc.M304594200. 
  • Shiraiwa H, Takei M, Yoshikawa T, Azuma T, Kato M, Mitamura K, Ueki T, Kida A, Horie T, Seki N, Sawada S (2004). "Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome". The Journal of International Medical Research. 32 (3): 284–91. PMID 15174222. doi:10.1177/147323000403200308. 
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