GRAFS

The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes.[1] As the vertebrate superfamily can be phylogenetically grouped into five main families the GRAFS classification system has been proposed.

GRAFS stands for Glutamate, Rhodopsin, Adhesion, Frizzled/Taste2, Secretin.[2]

References

  1. ↑ Lander, ES; Linton, LM; Birren; International Human Genome Sequencing, Consortium; et al. (Feb 15, 2001). "Initial sequencing and analysis of the human genome.". Nature. 409 (6822): 860–921. PMID 11237011. doi:10.1038/35057062.
  2. ↑ Fredriksson, R; Lagerström, MC; Lundin, LG; Schiöth, HB (June 2003). "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.". Molecular Pharmacology. 63 (6): 1256–72. PMID 12761335. doi:10.1124/mol.63.6.1256.


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