GPSM1

Identifiers

GPSM1, AGS3, G-protein signaling modulator 1, G protein signaling modulator 1

External IDs

MGI: 1915089 HomoloGene: 16987 GeneCards: GPSM1

Gene ontology
Molecular function	• protein binding • GTPase regulator activity • GDP-dissociation inhibitor activity
Cellular component	• cytoplasm • cytosol • Golgi membrane • plasma membrane • Golgi apparatus • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • protein complex
Biological process	• multicellular organism development • cell differentiation • regulation of catalytic activity • regulation of G-protein coupled receptor protein signaling pathway • nervous system development
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


26086


67839

Ensembl


ENSG00000160360


ENSMUSG00000026930

UniProt


Q86YR5


Q6IR34

RefSeq (mRNA)


NM_001145638 NM_001145639 NM_001200003 NM_015597


NM_001199146 NM_001199147 NM_153410

RefSeq (protein)


NP_001139110 NP_001139111 NP_001186932 NP_056412


NP_001186075 NP_001186076 NP_700459

Location (UCSC)

Chr 9: 136.33 – 136.36 Mb

Chr 2: 26.32 – 26.35 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.^[3]^[4]^[5]

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. PMID 11278352. doi:10.1074/jbc.M007573200.
↑ Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. PMID 10969064. doi:10.1074/jbc.C000509200.
1 2 "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin". J. Biol. Chem. 275 (52): 40981–5. PMID 11024022. doi:10.1074/jbc.M006478200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells". J. Biol. Chem. 278 (23): 20995–1002. PMID 12642577. doi:10.1074/jbc.M300917200.
Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression". Mol. Biol. Cell. 14 (8): 3144–55. PMC 181556 . PMID 12925752. doi:10.1091/mbc.E03-04-0212.
Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1". J. Biol. Chem. 278 (51): 51825–32. PMID 14530282. doi:10.1074/jbc.M306300200.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. PMID 15537540. doi:10.1016/j.cell.2004.10.028.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. PMID 16458856. doi:10.1016/j.bbrc.2006.01.050.

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GPSM1

References

Further reading