GKN1

GKN1

Identifiers

GKN1, AMP18, BRICD1, CA11, FOV, foveolin, gastrokine 1

External IDs

MGI: 1913533 HomoloGene: 10487 GeneCards: GKN1

Gene ontology
Molecular function	• molecular function
Cellular component	• extracellular region • extracellular space
Biological process	• digestion • positive regulation of cell division • regulation of cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


56287


66283


ENSG00000169605


ENSMUSG00000030050


Q9NS71


Q9CR36

RefSeq (mRNA)


NM_019617


NM_025466

RefSeq (protein)


NP_062563


NP_079742

Location (UCSC)

Chr 2: 68.97 – 68.98 Mb

Chr 6: 87.35 – 87.35 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.^[3]^[4]^[5]

The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG (Jul 2003). "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa". Am J Physiol Gastrointest Liver Physiol. 285 (2): G332–43. PMID 12851218. doi:10.1152/ajpgi.00453.2002.
↑ Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, Dono K, Umeshita K, Sakon M, Furukawa H, Hiratsuka M, Kasugai T, Ishiguro S, Monden M (Sep 2001). "Human stomach-specific gene, CA11, is down-regulated in gastric cancer". Int J Oncol. 19 (4): 701–7. PMID 11562744. doi:10.3892/ijo.19.4.701.
1 2 "Entrez Gene: GKN1 gastrokine 1".

Further reading

Yoshikawa Y, Mukai H, Hino F, et al. (2000). "Isolation of two novel genes, down-regulated in gastric cancer.". Jpn. J. Cancer Res. 91 (5): 459–63. PMID 10835488. doi:10.1111/j.1349-7006.2000.tb00967.x.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. PMC 403697 . PMID 12975309. doi:10.1101/gr.1293003.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Westley BR, Griffin SM, May FE (2005). "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C.". Biochemistry. 44 (22): 7967–75. PMID 15924415. doi:10.1021/bi047287n.
Walsh-Reitz MM, Huang EF, Musch MW, et al. (2005). "AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (1): G163–71. PMC 1444946 . PMID 15961882. doi:10.1152/ajpgi.00013.2005.
Nardone G, Rippa E, Martin G, et al. (2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection.". Digestive and Liver Disease. 39 (2): 122–9. PMID 17092786. doi:10.1016/j.dld.2006.09.017.

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