GFRA3
GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.[3][4]
Function
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.[4]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. PMID 9407096. doi:10.1074/jbc.272.52.33111.
- 1 2 "Entrez Gene: GFRA3 GDNF family receptor alpha 3".
Further reading
- Wang X, Baloh RH, Milbrandt J, Garcia KC (Jun 2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure (London, England : 1993). 14 (6): 1083–92. PMID 16765900. doi:10.1016/j.str.2006.05.010.
- Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science : A Publication of the Protein Society. 13 (10): 2819–24. PMC 2286551 . PMID 15340161. doi:10.1110/ps.04682504. Check date values in:
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(help) - Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. PMID 11360200. doi:10.1038/sj.onc.1204289.
- Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM (Sep 2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease". Journal of Medical Genetics. 37 (9): 674–9. PMC 1734691 . PMID 10978357. doi:10.1136/jmg.37.9.674.
- Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J (Dec 1998). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron. 21 (6): 1291–302. PMID 9883723. doi:10.1016/S0896-6273(00)80649-2. Check date values in:
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(help) - Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J (May 1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family". Proceedings of the National Academy of Sciences of the United States of America. 95 (10): 5801–6. PMC 20460 . PMID 9576965. doi:10.1073/pnas.95.10.5801.
- Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD (Feb 1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". European Journal of Biochemistry / FEBS. 251 (3): 622–30. PMID 9490034. doi:10.1046/j.1432-1327.1998.2510622.x.
- Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. PMID 7829101. doi:10.1006/geno.1994.1457. Check date values in:
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