GBF1

Identifiers

GBF1, ARF1GEF, golgi brefeldin A resistant guanine nucleotide exchange factor 1

External IDs

MGI: 1861607 HomoloGene: 37897 GeneCards: GBF1

Gene ontology
Molecular function	• phosphatidylinositol-3,5-bisphosphate binding • protein binding • guanyl-nucleotide exchange factor activity • phosphatidylinositol-3,4,5-trisphosphate binding • lipid binding • ARF guanyl-nucleotide exchange factor activity
Cellular component	• lipid droplet • Golgi membrane • trans-Golgi network • cell leading edge • peroxisome • cytoplasm • endoplasmic reticulum lumen • Golgi stack • mitochondrion • cytosol • Golgi apparatus • membrane • cis-Golgi network • endoplasmic reticulum-Golgi intermediate compartment
Biological process	• Golgi disassembly • protein localization to endoplasmic reticulum tubular network • retrograde vesicle-mediated transport, Golgi to ER • protein transport • Golgi organization • viral process • regulation of mitotic cell cycle • endoplasmic reticulum-Golgi intermediate compartment organization • post-Golgi vesicle-mediated transport • establishment of monopolar cell polarity • protein localization to endoplasmic reticulum exit site • regulation of protein localization to cell surface • ER to Golgi vesicle-mediated transport • cell activation involved in immune response • protein localization to Golgi apparatus • neutrophil chemotaxis • reactive oxygen species biosynthetic process • retrograde transport, endosome to Golgi • Golgi to endosome transport • regulation of ARF protein signal transduction • COPI coating of Golgi vesicle • positive regulation of GTPase activity • cellular response to virus • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8729


107338

Ensembl


ENSG00000107862


ENSMUSG00000025224

UniProt


Q92538


n/a

RefSeq (mRNA)


NM_001199378 NM_001199379 NM_004193


NM_178930

RefSeq (protein)


NP_001186307 NP_001186308 NP_004184


n/a

Location (UCSC)

Chr 10: 102.25 – 102.38 Mb

Chr 19: 46.15 – 46.29 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics. 54 (2): 323–7. PMID 9828135. doi:10.1006/geno.1998.5563.
↑ "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954. doi:10.1093/dnares/9.3.99.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502. doi:10.1093/dnares/3.5.321.
Claude A, Zhao BP, Kuziemsky CE, et al. (1999). "GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5.". J. Cell Biol. 146 (1): 71–84. PMC 2199737 . PMID 10402461. doi:10.1083/jcb.146.1.71.
Kawamoto K, Yoshida Y, Tamaki H, et al. (2003). "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat.". Traffic. 3 (7): 483–95. PMID 12047556. doi:10.1034/j.1600-0854.2002.30705.x.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor.". EMBO Rep. 4 (3): 320–5. PMC 1315890 . PMID 12634853. doi:10.1038/sj.embor.embor762.
Claude A, Zhao BP, Melançon P (2003). "Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity.". Biochem. Biophys. Res. Commun. 303 (1): 160–9. PMID 12646181. doi:10.1016/S0006-291X(03)00316-4.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature. 429 (6990): 375–81. PMID 15164054. doi:10.1038/nature02462.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. PMID 15324660. doi:10.1016/j.cub.2004.07.051.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Niu TK, Pfeifer AC, Lippincott-Schwartz J, Jackson CL (2005). "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi.". Mol. Biol. Cell. 16 (3): 1213–22. PMC 551486 . PMID 15616190. doi:10.1091/mbc.E04-07-0599.
Szul T, Garcia-Mata R, Brandon E, et al. (2005). "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.". Traffic. 6 (5): 374–85. PMID 15813748. doi:10.1111/j.1600-0854.2005.00282.x.
Roy SK, Hu J, Meng Q, et al. (2006). "Development of monoclonal antibodies against GBF1 and their use in studying its functions.". J. Interferon Cytokine Res. 25 (11): 666–73. PMID 16318580. doi:10.1089/jir.2005.25.666.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. PMC 1459365 . PMID 16565220. doi:10.1073/pnas.0507066103.
Zhao X, Claude A, Chun J, et al. (2006). "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic.". J. Cell. Sci. 119 (Pt 18): 3743–53. PMID 16926190. doi:10.1242/jcs.03173.
Belov GA, Altan-Bonnet N, Kovtunovych G, et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA.". J. Virol. 81 (2): 558–67. PMC 1797456 . PMID 17079330. doi:10.1128/JVI.01820-06.

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GBF1

References

Further reading