GATAD2B

GATAD2B

Identifiers

GATAD2B, MRD18, P66beta, p68, GATA zinc finger domain containing 2B

External IDs

MGI: 2443225 HomoloGene: 32484 GeneCards: GATAD2B

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • nucleosomal DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • sequence-specific DNA binding • zinc ion binding • protein binding • metal ion binding
Cellular component	• protein complex • nuclear chromatin • nuclear speck • nucleus • nucleoplasm
Biological process	• regulation of transcription, DNA-templated • transcription, DNA-templated • ATP-dependent chromatin remodeling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


57459


229542


ENSG00000143614 ENSG00000261992


ENSMUSG00000042390


Q8WXI9


Q8VHR5

RefSeq (mRNA)


NM_020699


NM_139304

RefSeq (protein)


NP_065750


NP_647465

Location (UCSC)

Chr 1: 153.79 – 153.92 Mb

Chr 3: 90.29 – 90.36 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.^[3]^[4]^[5]

Interactions

GATAD2B has been shown to interact with Methyl-CpG-binding domain protein 2,^[4]^[6] MBD3,^[4]^[6] RBBP7^[4] and RBBP4.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. PMID 10574461. doi:10.1093/dnares/6.5.329.
1 2 3 4 5 Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (Dec 2001). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol Cell Biol. 22 (2): 536–46. PMC 139742 . PMID 11756549. doi:10.1128/MCB.22.2.536-546.2002.
↑ "Entrez Gene: GATAD2B GATA zinc finger domain containing 2B".
1 2 Brackertz, Marc; Boeke Joern; Zhang Ru; Renkawitz Rainer (Oct 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. United States. 277 (43): 40958–66. ISSN 0021-9258. PMID 12183469. doi:10.1074/jbc.M207467200.

Further reading

Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.". J. Biol. Chem. 277 (43): 40958–66. PMID 12183469. doi:10.1074/jbc.M207467200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Brackertz M, Gong Z, Leers J, Renkawitz R (2006). "p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction.". Nucleic Acids Res. 34 (2): 397–406. PMC 1331983 . PMID 16415179. doi:10.1093/nar/gkj437.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.

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