GABRD
| GABRD | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | GABRD, EIG10, EJM7, GEFSP5, gamma-aminobutyric acid type A receptor delta subunit | ||||||
| External IDs | MGI: 95622 HomoloGene: 55489 GeneCards: GABRD | ||||||
| RNA expression pattern | |||||||
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| More reference expression data | |||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez | |||||||
| Ensembl | |||||||
| UniProt | |||||||
| RefSeq (mRNA) | |||||||
| RefSeq (protein) | |||||||
| Location (UCSC) | Chr 1: 2.02 – 2.03 Mb | Chr 4: 155.38 – 155.4 Mb | |||||
| PubMed search | [1] | [2] | |||||
| Wikidata | |||||||
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Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.[3][4][5]
Function
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. The GABAA receptor is generally pentameric. Its five subunits are alpha, beta, gamma, delta, and rho. The GABRD gene encodes the delta subunit.[5]
Cell type-specific expression
In a technical comparison between quantitative reverse transcriptase PCR and digital PCR, the expression of the rat gabrd gene was examined across three cell types in the somatosensory cortex: neurogliaform cells, fast spiking basket cells and pyramidal cells.[6] Gene expression was detected in all three cell types, but showed marked enrichment in neurogliaform cells versus the other cell types examined.[6]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Sommer B, Poustka A, Spurr NK, Seeburg PH (Oct 1990). "The murine GABAA receptor delta-subunit gene: structure and assignment to human chromosome 1". DNA and Cell Biology. 9 (8): 561–8. PMID 2176788. doi:10.1089/dna.1990.9.561.
- ↑ Emberger W, Windpassinger C, Petek E, Kroisel PM, Wagner K (Sep 2000). "Assignment of the human GABAA receptor delta-subunit gene (GABRD) to chromosome band 1p36.3 distal to marker NIB1364 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 89 (3-4): 281–2. PMID 10965146. doi:10.1159/000015636.
- 1 2 "Entrez Gene: GABRD gamma-aminobutyric acid (GABA) A receptor, delta".
- 1 2 Faragó N, Kocsis ÁK, Lovas S, Molnár G, Boldog E, Rózsa M, Szemenyei V, Vámos E, Nagy LI, Tamás G, Puskás LG (Jun 2013). "Digital PCR to determine the number of transcripts from single neurons after patch-clamp recording". BioTechniques. 54 (6): 327–36. PMID 23750542. doi:10.2144/000114029.
Further reading
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
- Lenzen KP, Heils A, Lorenz S, Hempelmann A, Sander T (Jun 2005). "Association analysis of the Arg220His variation of the human gene encoding the GABA delta subunit with idiopathic generalized epilepsy". Epilepsy Research. 65 (1-2): 53–7. PMID 16023832. doi:10.1016/j.eplepsyres.2005.04.005.
- Windpassinger C, Kroisel PM, Wagner K, Petek E (Jun 2002). "The human gamma-aminobutyric acid A receptor delta (GABRD) gene: molecular characterisation and tissue-specific expression". Gene. 292 (1-2): 25–31. PMID 12119096. doi:10.1016/S0378-1119(02)00649-2.
External links
- GABRD protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.