G6PC2

G6PC2
Identifiers
AliasesG6PC2, IGRP, glucose-6-phosphatase catalytic subunit 2
External IDsMGI: 1277193 HomoloGene: 41423 GeneCards: G6PC2
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57818

14378

Ensembl

ENSG00000278373
ENSG00000152254

ENSMUSG00000005232

UniProt

Q9NQR9

Q9Z186

RefSeq (mRNA)

NM_001081686
NM_021176

NM_001289856
NM_001289857
NM_021331

RefSeq (protein)

NP_001075155
NP_066999

NP_001276785
NP_001276786
NP_067306

Location (UCSC)Chr 2: 168.9 – 168.91 MbChr 2: 69.21 – 69.23 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Glucose-6-phosphatase 2 is an enzyme that in humans is encoded by the G6PC2 gene.[3][4][5]

Function

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined.[5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC (Mar 1999). "Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein". Diabetes. 48 (3): 531–42. PMID 10078553. doi:10.2337/diabetes.48.3.531.
  4. ↑ Ebert DH, Bischof LJ, Streeper RS, Chapman SC, Svitek CA, Goldman JK, Mathews CE, Leiter EH, Hutton JC, O'Brien RM (Mar 1999). "Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene". Diabetes. 48 (3): 543–51. PMID 10078554. doi:10.2337/diabetes.48.3.543.
  5. 1 2 "Entrez Gene: G6PC2 glucose-6-phosphatase, catalytic, 2".

Further reading

  • Martin CC, Bischof LJ, Bergman B, Hornbuckle LA, Hilliker C, Frigeri C, Wahl D, Svitek CA, Wong R, Goldman JK, Oeser JK, Leprêtre F, Froguel P, O'Brien RM, Hutton JC (2001). "Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes.". J. Biol. Chem. 276 (27): 25197–207. PMID 11297555. doi:10.1074/jbc.M101549200. 
  • Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP (2003). "Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8384–8. PMC 166238 Freely accessible. PMID 12815107. doi:10.1073/pnas.0932778100. 
  • Petrolonis AJ, Yang Q, Tummino PJ, Fish SM, Prack AE, Jain S, Parsons TF, Li P, Dales NA, Ge L, Langston SP, Schuller AG, An WF, Tartaglia LA, Chen H, Hong SB (2004). "Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP).". J. Biol. Chem. 279 (14): 13976–83. PMID 14722102. doi:10.1074/jbc.M307756200. 
  • Shieh JJ, Pan CJ, Mansfield BC, Chou JY (2004). "The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.". FEBS Lett. 562 (1–3): 160–4. PMID 15044018. doi:10.1016/S0014-5793(04)00223-6. 
  • Shieh JJ, Pan CJ, Mansfield BC, Chou JY (2006). "In islet-specific glucose-6-phosphatase-related protein, the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity". Diabetologia. 48 (9): 1851–9. PMID 16012821. doi:10.1007/s00125-005-1848-6. 
  • Yang J, Danke NA, Berger D, Reichstetter S, Reijonen H, Greenbaum C, Pihoker C, James EA, Kwok WW (2006). "Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects". J. Immunol. 176 (5): 2781–9. PMID 16493034. doi:10.4049/jimmunol.176.5.2781. 
  • Dogra RS, Vaidyanathan P, Prabakar KR, Marshall KE, Hutton JC, Pugliese A (2006). "Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas". Diabetologia. 49 (5): 953–7. PMID 16520917. doi:10.1007/s00125-006-0185-8. 
  • Unger WW, Pinkse GG, Mulder-van der Kracht S, van der Slik AR, Kester MG, Ossendorp F, Drijfhout JW, Serreze DV, Roep BO (2007). "Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men". Ann. N. Y. Acad. Sci. 1103: 192–5. PMID 17376840. doi:10.1196/annals.1394.024. 
  • Li DZ, Liao C, Tang XW (2007). "Prenatal diagnosis of glycogen storage disease type Ia, presenting a new mutation in the glucose-6-phosphatase gene". Prenat. Diagn. 27 (7): 685–6. PMID 17607665. doi:10.1002/pd.1764. 


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