Fucosylation

Fucosylation is the process of adding fucose sugar units to a molecule. It is a type of glycosylation.

It is important clinically,[1][2] especially in cancer.[3][4]

It is performed by fucosyltransferase enzymes.

References

  1. ↑ Ma, B.; Simala-Grant, J. L.; Taylor, D. E. (2006). "Fucosylation in prokaryotes and eukaryotes". Glycobiology. 16 (12): 158R–184R. PMID 16973733. doi:10.1093/glycob/cwl040.
  2. ↑ Miyoshi, E.; Moriwaki, K.; Nakagawa, T. (2007). "Biological Function of Fucosylation in Cancer Biology". Journal of Biochemistry. 143 (6): 725–729. PMID 18218651. doi:10.1093/jb/mvn011.
  3. ↑ Miyoshi, Eiji (2008). "Fucosylation and Cancer". Experimental Glycoscience: 235–237. ISBN 978-4-431-77921-6. doi:10.1007/978-4-431-77922-3_57.
  4. ↑ Nakagawa, T.; Uozumi, N; Nakano, M; Mizuno-Horikawa, Y; Okuyama, N; Taguchi, T; Gu, J; Kondo, A; et al. (2006). "Fucosylation of N-Glycans Regulates the Secretion of Hepatic Glycoproteins into Bile Ducts". Journal of Biological Chemistry. 281 (40): 29797–29806. PMID 16899455. doi:10.1074/jbc.M605697200.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.