Fluorodopa

Fluorodopa
Identifiers

IUPAC name 2-fluoro-5-hydroxy-L-tyrosine
Synonyms	6-fluoro-L-DOPA FDOPA
CAS Number	75290-51-6
ChemSpider	96897
UNII	6WIZ27OUZ9
Chemical and physical data
Formula	C₉H₁₀FNO₄
Molar mass	215.18 g/mol
3D model (JSmol)	Interactive image
SMILES C1=C(C(=CC(=C1O)O)F)C[C@@H](C(=O)O)N
InChI InChI=1S/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1 Key:PAXWQORCRCBOCU-LURJTMIESA-N

Fluorodopa, also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET).^[1] Fluorodopa PET scanning is a valid method for assessing the functional state of the nigrostriatal dopaminergic pathway. It is particularly useful for studies requiring repeated measures such as examinations of the course of a disease and the effect of treatment

References

↑ -Deng WP, Wong KA, Kirk KL (2002). "Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA". Tetrahedron: Asymmetry. 13 (11): 1135–1140. doi:10.1016/S0957-4166(02)00321-X.

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