FLOT1

Identifiers

FLOT1, flotillin 1

External IDs

MGI: 1100500 HomoloGene: 31337 GeneCards: FLOT1

Gene ontology
Molecular function	• protease binding • protein binding • protein heterodimerization activity • ionotropic glutamate receptor binding
Cellular component	• integral component of membrane • endosome • membrane • cell-cell contact zone • focal adhesion • plasma membrane raft • melanosome • plasma membrane • centriolar satellite • cell-cell adherens junction • microtubule organizing center • lysosomal membrane • flotillin complex • uropod • basolateral plasma membrane • early endosome • apical plasma membrane • cortical actin cytoskeleton • caveola • membrane raft • COP9 signalosome • sarcolemma • extracellular exosome • cytoplasmic vesicle • lamellipodium • cell-cell junction
Biological process	• positive regulation of cell-cell adhesion mediated by cadherin • positive regulation of cell adhesion molecule production • positive regulation of protein phosphorylation • regulation of toll-like receptor 4 signaling pathway • positive regulation of heterotypic cell-cell adhesion • positive regulation of toll-like receptor 3 signaling pathway • axonogenesis • positive regulation of skeletal muscle tissue development • positive regulation of cytokine production • extracellular matrix disassembly • protein kinase C signaling • response to endoplasmic reticulum stress • positive regulation of myoblast fusion • positive regulation of endocytosis • positive regulation of cell junction assembly • protein localization to membrane raft • membrane raft assembly • cellular response to exogenous dsRNA • regulation of receptor internalization • positive regulation of synaptic transmission, dopaminergic • positive regulation of protein binding • regulation of Rho protein signal transduction • protein homooligomerization • dsRNA transport • plasma membrane raft assembly • positive regulation of interferon-beta production • protein stabilization • protein localization to plasma membrane
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10211


14251

Ensembl

ENSG00000137312 ENSG00000232280 ENSG00000224740 ENSG00000206480 ENSG00000206379
ENSG00000230143 ENSG00000236271 ENSG00000223654


ENSMUSG00000059714

UniProt


O75955


O08917

RefSeq (mRNA)


NM_005803 NM_001318875


NM_008027

RefSeq (protein)


NP_001305804 NP_005794


NP_032053

Location (UCSC)

Chr 6: 30.73 – 30.74 Mb

Chr 17: 35.82 – 35.83 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.^[3]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.^[4] The function of flotillin 1 has not been determined.^[3]

Interactions

FLOT1 has been shown to interact with SORBS1.^[5]^[6]^[7]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: FLOT1 flotillin 1".
↑ Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. PMID 9153235. doi:10.1074/jbc.272.21.13793.
↑ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. 117 (Pt 12): 2557–68. PMID 15128873. doi:10.1242/jcs.01148.
↑ Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport". Nature. 407 (6801): 202–7. PMID 11001060. doi:10.1038/35025089.
↑ Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. PMC 55379 . PMID 11481476. doi:10.1073/pnas.151252898.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.". J. Biol. Chem. 274 (18): 12702–9. PMID 10212252. doi:10.1074/jbc.274.18.12702.
Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.". J. Cell. Biochem. 75 (1): 147–59. PMID 10462713. doi:10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. PMC 16901 . PMID 10931946. doi:10.1073/pnas.160270997.
Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport.". Nature. 407 (6801): 202–7. PMID 11001060. doi:10.1038/35025089.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMC 310934 . PMID 11042152. doi:10.1101/gr.140200.
Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.". Blood. 97 (4): 1141–3. PMID 11159550. doi:10.1182/blood.V97.4.1141.
Edgar AJ, Polak JM (2001). "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals.". Int. J. Biochem. Cell Biol. 33 (1): 53–64. PMID 11167132. doi:10.1016/S1357-2725(00)00069-8.
Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. PMC 55379 . PMID 11481476. doi:10.1073/pnas.151252898.
Stuermer CA, Lang DM, Kirsch F, et al. (2002). "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2.". Mol. Biol. Cell. 12 (10): 3031–45. PMC 60153 . PMID 11598189. doi:10.1091/mbc.12.10.3031.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Girardot N, Allinquant B, Duyckaerts C (2004). "[Lipid rafts, flotillin-1 and Alzheimer disease]". J. Soc. Biol. 197 (3): 223–9. PMID 14708344.
Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). "Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein.". Biochem. Biophys. Res. Commun. 318 (2): 453–60. PMID 15120622. doi:10.1016/j.bbrc.2004.04.045.
Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.". J. Cell. Sci. 117 (Pt 12): 2557–68. PMID 15128873. doi:10.1242/jcs.01148.
Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.". Mol. Biol. Cell. 15 (12): 5399–407. PMC 532019 . PMID 15469992. doi:10.1091/mbc.E04-03-0182.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Jacobowitz DM, Kallarakal AT (2005). "Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain.". Neurotoxicity research. 6 (4): 245–57. PMID 15545008. doi:10.1007/BF03033435.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. PMID 15862967. doi:10.1016/j.jsbmb.2005.01.007.
Glebov OO, Bright NA, Nichols BJ (2006). "Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells.". Nat. Cell Biol. 8 (1): 46–54. PMID 16341206. doi:10.1038/ncb1342.

External links

FLOT1 human gene location in the UCSC Genome Browser.
FLOT1 human gene details in the UCSC Genome Browser.

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FLOT1

Interactions

References

Further reading

External links