Faecalibacterium
| Faecalibacterium | |
|---|---|
| Scientific classification | |
| Domain: | Bacteria |
| Phylum: | Firmicutes |
| Class: | Clostridia |
| Order: | Clostridiales |
| Family: | Clostridiaceae |
| Genus: | Faecalibacterium Duncan et al., 2002 |
| Species: | F. prausnitzii |
| Binomial name | |
| Faecalibacterium prausnitzii (Hauduroy et al., 1937) Duncan et al., 2002 | |
Faecalibacterium is a genus of bacteria. Its sole known species, Faecalibacterium prausnitzii is one of the most abundant and important commensal bacterium of the human gut microbiota. These bacteria mainly produces butyrate and other short-chain fatty acids through the fermentation of dietary fiber.Formerly considered to be a member of Fusobacterium, the bacterium is named in honor of German bacteriologist Otto Prausnitz. Phylogenetically F. prausnitzii, belongs to phylogroup i and ii. Most of the new isolates of these bacteria isolated by M. Tanweer Khan belong to phylogroup ii.[1]
Clinical relevance
In healthy adults, Faecalibacterium prausnitzii represent more than 5% of the bacteria in the intestine, making it one of the most common gut bacteria. It boosts our immune system, and many other things.[2] Lower than usual levels of F. prausnitzii in the intestines have been associated with Crohn's Disease, obesity, asthma and Major Depressive Disorder. [3][4][5][6]
References
- ↑ Lopez-Siles, Mireia; Khan, Tanweer M.; Duncan, Sylvia H.; Harmsen, Hermie J. M.; Garcia-Gil, L. Jesús; Flint, Harry J. (2012-01-15). "Cultured Representatives of Two Major Phylogroups of Human Colonic Faecalibacterium prausnitzii Can Utilize Pectin, Uronic Acids, and Host-Derived Substrates for Growth". Applied and Environmental Microbiology. 78 (2): 420–428. ISSN 0099-2240. PMC 3255724
. PMID 22101049. doi:10.1128/AEM.06858-11. - ↑ Miquel, S; Martín, R; Rossi, O; Bermúdez-Humarán, LG; Chatel, JM; Sokol, H; Thomas, M; Wells, JM; Langella, P (2013). "Faecalibacterium prausnitzii and human intestinal health". Current Opinion in Microbiology. 16 (3): 255–61. PMID 23831042. doi:10.1016/j.mib.2013.06.003.
- ↑ "Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients". Proceedings of the National Academy of Sciences of the United States of America. September 8, 2008. Retrieved 2008-10-21.
- ↑ "Bacterium 'to blame for Crohn's'". BBC News. 2008-10-21. Retrieved 2008-10-21.
- ↑ Newton, Ryan J.; McLellan, Sandra L.; Dila, Deborah K.; Vineis, Joseph H.; Morrison, Hilary G.; Eren, A. Murat; Sogin, Mitchell L. (2015). "Sewage Reflects the Microbiomes of Human Populations". MBio. 6 (2): e02574–14. PMC 4358014 . PMID 25714718. doi:10.1128/mBio.02574-14.
- ↑ Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, Wang W, Tang W, Tan Z, Shi J, Li L, Ruan B (April 13, 2015). "Altered fecal microbiota composition in patients with major depressive disorder.". Brain Behav. Immun. NCBI. 48: 186–94. PMID 25882912. doi:10.1016/j.bbi.2015.03.016.