Folylpolyglutamate synthase

FPGS
Identifiers
AliasesFPGS, folylpolyglutamate synthase
External IDsMGI: 95576 HomoloGene: 6997 GeneCards: FPGS
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2356

14287

Ensembl

ENSG00000136877

ENSMUSG00000009566

UniProt

Q05932

P48760

RefSeq (mRNA)

NM_001018078
NM_001288803
NM_004957

NM_010236

RefSeq (protein)

NP_001018088
NP_001275732
NP_004948

NP_034366

Location (UCSC)Chr 9: 127.79 – 127.81 MbChr 2: 32.68 – 32.7 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Folylpolyglutamate synthase, mitochondrial is an enzyme that in humans is encoded by the FPGS gene.[3]

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:<div class="noresize thumb tnone" style="; "> <div class="thumbinner" style="overflow:hidden;width:701px;"> <div class="thumbimage" style=" overflow:hidden; position:relative; background-color:white;"> <div style=";left:0px; top:0px; width:699px; position:absolute;"> <imagemap> Image:FluoropyrimidineActivity_WP1601.png|right|alt=FluoropyrimidineActivity_WP1601 rect 174.0 70.0 232.0 90.0 go to article rect 308.0 82.0 361.0 102.0 go to article rect 308.0 62.0 361.0 82.0 go to article rect 224.0 25.0 328.0 45.0 go to pathway article rect 238.0 207.0 289.0 227.0 go to pathway article rect 72.0 115.0 123.0 135.0 go to article rect 54.0 173.0 113.0 193.0 go to article rect 519.0 107.0 599.0 127.0 go to article rect 436.5 92.0 480.5 112.0 go to article rect 436.5 112.0 480.5 132.0 go to article rect 403.0 150.0 437.0 170.0 go to article rect 344.0 125.0 390.0 145.0 go to article rect 344.0 145.0 390.0 165.0 go to article rect 344.0 165.0 390.0 185.0 go to article rect 245.0 347.0 284.0 367.0 go to PubChem Compound rect 350.0 233.0 394.0 253.0 go to article rect 440.0 297.0 484.0 317.0 go to article rect 544.0 296.0 588.0 316.0 go to article rect 321.0 395.0 365.0 415.0 go to article rect 311.0 305.0 357.0 325.0 go to article rect 311.0 325.0 357.0 345.0 go to article rect 321.0 415.0 365.0 435.0 go to article rect 188.0 288.0 232.0 308.0 go to article rect 188.0 308.0 232.0 328.0 go to article rect 53.0 321.0 97.0 341.0 go to article rect 75.0 254.0 121.0 274.0 go to article rect 197.0 443.0 241.0 463.0 go to article rect 197.0 463.0 241.0 483.0 go to article rect 208.5 804.0 252.5 824.0 go to article rect 326.5 561.0 370.5 581.0 go to article rect 326.5 521.0 370.5 541.0 go to article rect 326.5 541.0 370.5 561.0 go to article rect 491.0 540.0 547.0 560.0 go to article rect 414.0 475.0 453.0 495.0 go to pathway article rect 418.0 610.0 457.0 630.0 go to pathway article rect 79.0 861.0 242.0 881.0 go to article rect 164.0 907.0 241.0 927.0 go to article rect 288.0 849.0 332.0 869.0 go to article rect 308.0 887.0 352.0 907.0 go to article rect 437.0 811.0 517.0 831.0 go to article rect 389.0 858.0 469.0 878.0 go to WikiPathways rect 487.5 837.0 531.5 857.0 go to article rect 386.5 885.0 430.5 905.0 go to article rect 430.5 885.0 474.5 905.0 go to article rect 386.5 905.0 430.5 925.0 go to article rect 430.5 905.0 474.5 925.0 go to article rect 180.5 961.0 224.5 981.0 go to article rect 224.5 961.0 268.5 981.0 go to article rect 180.5 941.0 224.5 961.0 go to article rect 224.5 941.0 268.5 961.0 go to article default Go to pathway article desc none </imagemap>
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article

|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

Further reading


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