FOLFOXIRI
FOLFOXIRI is a chemotherapy regimen for treatment of advanced colorectal cancer.[1] [2][3][4][5] The role of FOLFOXIRI in colorectal cancer has been reviewed.[1][6]
The chemotherapy regimen is made up of the following four drugs:
- FOL – folinic acid (leucovorin), a vitamin B derivative that modulates/potentiates/reduces the side effects of fluorouracil;
- F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops DNA synthesis;
- OX – oxaliplatin (Eloxatin), a platinum-based antineoplastic agent, which inhibits DNA repair and/or DNA synthesis;
- IRI – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling and duplicating.
It is usually given with bevacizumab,[7] unlike FOLFIRINOX for treatment of advanced pancreatic cancer. Also, the doses (Day 1: irinotecan 165 mg/m2 IV, plus oxaliplatin 85 mg/m2 IV; Day 1: leucovorin 400 mg/m2; Days 1–3: fluorouracil 1,600 mg/m2/day × 2 days (total 3,200 mg/m2 over 48 hours) continuous infusion starting on day 1; Day 1: bevacizumab 5 mg/kg IV; repeat cycle every 2 weeks)[1][8][9] are slightly dissimilar to FOLFIRINOX.
Upfront FOLFOXIRI with bevacizumab can be followed by fluoropyrimidine with bevacizumab maintenance.[10]
See also
References
- 1 2 3 Nipp RD, Ryan DP (2015). "Should FOLFOXIRI plus bevacizumab Be the standard first-line therapy in metastatic colorectal cancer?". Oncologist. 20 (3): 236–8. PMC 4350810
. PMID 25660156. doi:10.1634/theoncologist.2014-0495. - ↑ FOLFOXIRI plus bevacizumab (bev) versus FOLFIRI plus bev as first-line treatment of metastatic colorectal cancer (mCRC): Updated survival results of the phase III TRIBE trial by the GONO group. J Clin Oncol 33, 2015 (suppl 3; abstr 657)
- ↑ Akhtar R, Chandel S, Sarotra P, Medhi B (2014). "Current status of pharmacological treatment of colorectal cancer". World J Gastrointest Oncol. 6 (6): 177–83. PMC 4058725 . PMID 24936228. doi:10.4251/wjgo.v6.i6.177.
- ↑ ESMO. First-Line FOLFOXIRI/Bevacizumab Improves Long-Term Outcomes in Metastatic Colorectal Cancer. Updated survival results of the phase III TRIBE study.
- ↑ Cremolini C, Loupakis F, Antoniotti C et al. (2015). "FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study". Lancet Oncol. 16 (13): 1306–15. PMID 26338525. doi:10.1016/S1470-2045(15)00122-9.
- ↑ Stein A, Glockzin G, Wienke A et al. (2012). "Treatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: presentation of two novel trials (CHARTA and PERIMAX) and review of the literature". BMC Cancer. 12: 356. PMC 3503684 . PMID 22897915. doi:10.1186/1471-2407-12-356.
- ↑ Loupakis F, Cremolini C, Masi G et al. (2014). "Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer". N. Engl. J. Med. 371 (17): 1609–18. PMID 25337750. doi:10.1056/NEJMoa1403108.
- ↑ http://www.cancertherapyadvisor.com/gastrointestinal-cancers/colon-cancer-treatment-regimens/article/218158/
- ↑ Falcone A, Ricci S, Brunetti I et al. (2007). "Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest". J. Clin. Oncol. 25 (13): 1670–6. PMID 17470860. doi:10.1200/JCO.2006.09.0928.
- ↑ Stein A, Atanackovic D, Hildebrandt B et al. (2015). "Upfront FOLFOXIRI plus bevacizumab followed by fluoropyrimidin and bevacizumab maintenance in patients with molecularly unselected metastatic colorectal cancer". Br. J. Cancer. 113 (6): 872–7. PMID 26335608. doi:10.1038/bjc.2015.299.
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