FMN riboswitch

FMN riboswitch (RFN element)

Identifiers
Symbol FMN
Alt. Symbols RFN
Rfam RF00050
Other data
RNA type Cis-reg; riboswitch
Domain(s) Bacteria
GO 0010181
SO 0000035
A representation of the 3D structure of the FMN riboswitch. This derived from a crystal structure of the FMN riboswitch bound to FMN.[1]

The FMN riboswitch (also known as RFN element) is a highly conserved RNA element that is found frequently in the 5'-untranslated regions of prokaryotic mRNAs that encode for flavin mononucleotide (FMN) biosynthesis and transport proteins.[2][3] This element is a metabolite-dependent riboswitch that directly binds FMN in the absence of proteins.[4] In Bacillus subtilis, the riboswitch controls gene expression by causing premature transcription termination within the 5' untranslated region of the ribDEAHT operon and precluding access to the ribosome-binding site of ypaA mRNA.[4][5]

References

  1. ↑ Serganov A, Huang L, Patel DJ (2009). "Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch.". Nature. 458 (7235): 233–7. PMID 19169240. doi:10.1038/nature07642.
  2. ↑ Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS (2002). "Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.". Nucleic Acids Res. 30 (14): 3141–51. PMC 135753 Freely accessible. PMID 12136096. doi:10.1093/nar/gkf433.
  3. ↑ Gelfand MS, Mironov AA, Jomantas J, Kozlov YI, Perumov DA (1999). "A conserved RNA structure element involved in the regulation of bacterial riboflavin synthesis genes.". Trends Genet. 15 (11): 439–42. PMID 10529804. doi:10.1016/S0168-9525(99)01856-9.
  4. 1 2 Mironov, AS; Gusarov I; Rafikov R; Lopez LE; Shatalin K; Kreneva RA; Perumov DA; Nudler E (2002). "Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria". Cell. 111 (5): 747–756. PMID 12464185. doi:10.1016/S0092-8674(02)01134-0.
  5. ↑ Winkler, WC; Cohen-Chalamish S; Breaker RR (2002). "An mRNA structure that controls gene expression by binding FMN". Proc Natl Acad Sci USA. 99 (25): 15908–15913. PMC 138538 Freely accessible. PMID 12456892. doi:10.1073/pnas.212628899.


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