FLRT3

FLRT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CMN, 5CMP
Identifiers
Aliases	FLRT3, HH21, fibronectin leucine rich transmembrane protein 3
External IDs	MGI: 1918686 HomoloGene: 8322 GeneCards: FLRT3
Gene ontology Molecular function • protein binding, bridging • signal transducer activity, downstream of receptor • protein homodimerization activity • fibroblast growth factor receptor binding • protein kinase inhibitor activity • protein binding • chemorepellent activity Cellular component • cytoplasm • axon terminus • integral component of membrane • synaptic membrane • cell projection • endoplasmic reticulum membrane • membrane • cell-cell junction • focal adhesion • proteinaceous extracellular matrix • axonal growth cone • integral component of plasma membrane • extracellular region • axon • cell junction • endoplasmic reticulum • plasma membrane • extracellular space Biological process • negative chemotaxis • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • head development • neuron projection extension • axon guidance • multicellular organism development • heart development • cell adhesion • response to axon injury • embryonic morphogenesis • proepicardium cell migration involved in pericardium morphogenesis • synapse assembly • neuron projection development • negative regulation of JAK-STAT cascade • positive regulation of synapse assembly • fibroblast growth factor receptor signaling pathway • cell-cell adhesion via plasma-membrane adhesion molecules Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23767	71436
Ensembl	ENSG00000125848	ENSMUSG00000051379
UniProt	Q9NZU0	Q8BGT1
RefSeq (mRNA)	NM_013281 NM_198391	NM_001172160 NM_178382
RefSeq (protein)	NP_037413 NP_938205	NP_001165631 NP_848469
Location (UCSC)	Chr 20: 14.32 – 14.34 Mb	Chr 2: 140.65 – 140.67 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.^[3][4]

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[4]

References

Further reading