FLRT2

FLRT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V2C, 4V2D
Identifiers
Aliases	FLRT2, fibronectin leucine rich transmembrane protein 2
External IDs	MGI: 3603594 HomoloGene: 8291 GeneCards: FLRT2
Gene ontology Molecular function • protein binding, bridging • signal transducer activity, downstream of receptor • fibroblast growth factor receptor binding • protein kinase inhibitor activity • chemorepellent activity Cellular component • cytoplasm • organelle membrane • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • cell-cell junction • focal adhesion • proteinaceous extracellular matrix • synapse • integral component of plasma membrane • extracellular region • cell junction • endoplasmic reticulum • neuron projection • extracellular exosome • plasma membrane • extracellular space Biological process • negative chemotaxis • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • cell adhesion involved in heart morphogenesis • heart morphogenesis • axon guidance • multicellular organism development • cell adhesion • basement membrane organization • regulation of neuron migration • negative regulation of JAK-STAT cascade • positive regulation of synapse assembly • fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23768	399558
Ensembl	ENSG00000185070	ENSMUSG00000047414
UniProt	O43155	Q8BLU0
RefSeq (mRNA)	NM_001346143 NM_001346144 NM_001346145 NM_001346146 NM_013231	NM_201518
RefSeq (protein)	NP_001333072 NP_001333073 NP_001333074 NP_001333075 NP_037363	NP_958926
Location (UCSC)	Chr 14: 85.53 – 85.65 Mb	Chr 12: 95.69 – 95.79 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.^[3][4][5]

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix.^[5]

References

Further reading