FGFBP1

Identifiers

FGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1

External IDs

MGI: 1096350 HomoloGene: 3766 GeneCards: FGFBP1

Gene ontology
Molecular function	• fibroblast growth factor binding • heparin binding • protein binding • growth factor binding
Cellular component	• extracellular region • cell surface • plasma membrane • membrane • extracellular space
Biological process	• positive regulation of fibroblast growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • signal transduction • positive regulation of cell proliferation • negative regulation of cell proliferation • cell-cell signaling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9982


14181

Ensembl


ENSG00000137440


ENSMUSG00000048373

UniProt


Q14512


O70514

RefSeq (mRNA)


NM_005130


NM_001271616 NM_008009

RefSeq (protein)


NP_005121


NP_001258545 NP_032035

Location (UCSC)

Chr 4: 15.94 – 15.94 Mb

Chr 5: 43.98 – 43.98 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.^[3]^[4]^[5]

FGFBP1, or HBP17, binds to both acidic (FGF1; MIM 131220) and basic (FGF2; MIM 134920) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2; MIM 142461).[supplied by OMIM]^[5]

Interactions

FGFBP1 has been shown to interaction with Perlecan.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. PMID 11148217. doi:10.1074/jbc.M011493200.
↑ Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. PMID 1885605.
1 2 "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Abuharbeid S, Czubayko F, Aigner A (2006). "The fibroblast growth factor-binding protein FGF-BP.". Int. J. Biochem. Cell Biol. 38 (9): 1463–8. PMID 16324873. doi:10.1016/j.biocel.2005.10.017.
Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features.". Biochemistry. 15 (21): 4687–93. PMID 9982. doi:10.1021/bi00666a023.
Czubayko F, Liaudet-Coopman ED, Aigner A, et al. (1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.". Nat. Med. 3 (10): 1137–40. PMID 9334727. doi:10.1038/nm1097-1137.
Wang XC, Chen JH, Crab JW, Sato JD (1998). "Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site.". Biochem. Mol. Biol. Int. 46 (1): 81–7. PMID 9784842. doi:10.1080/15216549800203582.
Harris VK, Coticchia CM, Kagan BL, et al. (2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways.". J. Biol. Chem. 275 (15): 10802–11. PMID 10753873. doi:10.1074/jbc.275.15.10802.
Sauter ER, Nesbit M, Tichansky D, et al. (2001). "Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium.". Int. J. Cancer. 92 (3): 374–81. PMID 11291074. doi:10.1002/ijc.1207.
Chen JH, Wang XC, Sato JD (2001). "Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells.". Cell Biol. Int. 25 (6): 567–70. PMID 11407864. doi:10.1006/cbir.2000.0688.
Tassi E, Al-Attar A, Aigner A, et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein.". J. Biol. Chem. 276 (43): 40247–53. PMID 11509569. doi:10.1074/jbc.M104933200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Beer HD, Bittner M, Niklaus G, et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.". Oncogene. 24 (34): 5269–77. PMID 15806171. doi:10.1038/sj.onc.1208560.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Xie B, Tassi E, Swift MR, et al. (2006). "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.". J. Biol. Chem. 281 (2): 1137–44. PMID 16257968. doi:10.1074/jbc.M510754200.
Ray PE, Tassi E, Liu XH, Wellstein A (2006). "Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome.". Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (1): R105–13. PMID 16352855. doi:10.1152/ajpregu.00492.2005.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.

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FGFBP1

Interactions

References

Further reading