FBXO6
| FBXO6 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | FBXO6, FBG2, FBS2, FBX6, Fbx6b, F-box protein 6 | ||||||
| External IDs | MGI: 1354743 HomoloGene: 9274 GeneCards: FBXO6 | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez | |||||||
| Ensembl | |||||||
| UniProt | |||||||
| RefSeq (mRNA) | |||||||
| RefSeq (protein) | |||||||
| Location (UCSC) | Chr 1: 11.66 – 11.67 Mb | Chr 4: 148.15 – 148.15 Mb | |||||
| PubMed search | [1] | [2] | |||||
| Wikidata | |||||||
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F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.[3][4][5]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. PMID 10531035. doi:10.1016/S0960-9822(00)80020-2.
- ↑ Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (Nov 2000). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. PMID 10945468. doi:10.1006/geno.2000.6211.
- 1 2 "Entrez Gene: FBXO6 F-box protein 6".
Further reading
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504. - Yoshida Y, Tokunaga F, Chiba T, et al. (2003). "Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.". J. Biol. Chem. 278 (44): 43877–84. PMID 12939278. doi:10.1074/jbc.M304157200.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins.". Gene. 296 (1-2): 11–20. PMID 12383498. doi:10.1016/S0378-1119(02)00867-3.
- Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. PMID 10531037. doi:10.1016/S0960-9822(00)80021-4.